Store lyophilized at 2-8°C for 6 month or at -20°C long term. After reconstitution store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C long term. Avoid repeated freezing and thawing. Shelf life: one year from despatch.
Haltbarkeit
12 months
Target
GPR50
(G Protein-Coupled Receptor 50 (GPR50))
Andere Bezeichnung
gpr50
Hintergrund
GPR50 or me latonin - related receptor is a 617 amino acid protein that belongs to the G - protein coupled receptor 1 family, containing one disulfide bond. GPR50 does not bind melatonin and its end ogenous ligand is still unknown. Nevertheless, this receptor has been shown to behave as an antagonist of the melatonin receptor MT 1. GPR50 has been identified as a genetic risk factor for bipolar disorder and major depression in women, and it has been linked to neurite outgrowth, lipid metabolism, stress response and energy homeostasis and torpor. Its expression seems to be limited to brain, particularly the hypothalamus and pituitary.