P-Selectin Antikörper (Biotin)

Produktnummer ABIN5541729

Der Maus Monoklonal anti-P-Selectin Antikörper wird verwendet zum Nachweis von P-Selectin in Proben von Human und Primate. Er wurde validiert für FACS.

Kurzübersicht für P-Selectin Antikörper (Biotin) (ABIN5541729)

Target: P-Selectin (SELP) (Selectin P (Granule Membrane Protein 140kDa, Antigen CD62) (SELP))

Reaktivität: Human, Primate

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser P-Selectin Antikörper ist konjugiert mit Biotin

Applikation: Flow Cytometry (FACS)

Klon: AK4

Produktdetails anti-P-Selectin Antikörper (Biotin)

Spezifität: This antibody recognizes CD62P (P-selectin), a 140 kD single chain type I transmembrane glycoprotein present in secretory alpha-granules in platelets, in Weibel-Palade bodies in endothelial cells and in megakaryocytes it is relocated to the plasma membrane upon activation.

Immunogen: Human platelets

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Flow cytometry.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store undiluted at 2-8°C. DO NOT FREEZE! Shelf life: one year from despatch.

Haltbarkeit: 12 months

Details zu P-Selectin

Target: P-Selectin (SELP) (Selectin P (Granule Membrane Protein 140kDa, Antigen CD62) (SELP))

Andere Bezeichnung: cd62p,p-selectin

Hintergrund: CD62P (P-selectin) is an adhesion glycoprotein that is expressed on platelets and endothelial cells upon their activation. Interaction between CD62P and its mucin-like ligand PSGL-1 (P-selectin glycoprotein ligand-1) expressed on the microvilli of most leukocytes supports leukocyte rolling along postkapillary venules at the earliest time of inflammation. Both CD62P and PSGL-1 are extended glycoproteins that form homodimers. CD62P dimerization is probably mediated through interactions of the transmembrane domains and stabilizes leukocyte tethering and rolling, probably by increasing rebinding within a bond cluster.

UniProt: P16109