ACOX1 Antikörper

Produktnummer ABIN5541563

Dieser Maus Monoklonal Antikörper detektiert spezifisch ACOX1 in WB, IF, ICC und IHC (p). Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für ACOX1 Antikörper (ABIN5541563)

Target: ACOX1 (Acyl-CoA Oxidase 1, Palmitoyl (ACOX1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser ACOX1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: 153CT43-1-1

Produktdetails anti-ACOX1 Antikörper

Spezifität: This antibody recognizes Human ACOX1. Other species not tested.

Aufreinigung: Protein G Chromatography, followed by dialysis against PBS

Immunogen: ACOX1 recombinant protein.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Western blot: 1/100-1/500. Immunofluorescence: 1/10-1/50. Immunohistochemistry on Paraffin Sections: 1/10-1/50.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS Preservatives: 0.09 % (W/V) Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.

Haltbarkeit: 12 months

Details zu ACOX1

Target: ACOX1 (Acyl-CoA Oxidase 1, Palmitoyl (ACOX1))

Andere Bezeichnung: acox1

Hintergrund: ACOX1 is the first enzyme of the fatty acid beta-oxidation pathway, which catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl-CoAs. It donates electrons directly to molecular oxygen, thereby producing hydrogen peroxide. Defects in this gene result in pseudoneonatal adrenoleukodystrophy, a disease that is characterized by accumulation of very long chain fatty acids. Function: Catalyzes the desaturation of acyl-CoAs to 2-trans- enoyl-CoAs. Isoform 1 shows highest activity against medium-chain fatty acyl-CoAs and activity decreases with increasing chain length. Isoform 2 is active against a much broader range of substrates and shows activity towards very long-chain acyl-CoAs. Isoform 2 is twice as active as isoform 1 against 16-hydroxy- palmitoyl-CoA and is 25 % more active against 1,16-hexadecanodioyl- CoA. Cellular Location: Peroxisome. Tissue Location: Widely expressed with highest levels of isoform 1 and isoform 2 detected in testis. Isoform 1 is expressed at higher levels than isoform 2 in liver and kidney while isoform 2 levels are higher in brain, lung, muscle, white adipose tissue and testis. Levels are almost equal in heart.

UniProt: Q15067

Pathways: Regulation of Lipid Metabolism by PPARalpha, Monocarboxylic Acid Catabolic Process