LARGE Antikörper (AA 35-142)

Produktnummer ABIN5541530

Dieses Maus Monoklonal-Antikörper erkennt spezifisch LARGE in WB und FACS. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für LARGE Antikörper (AA 35-142) (ABIN5541530)

Target: LARGE (Like-Glycosyltransferase (LARGE))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser LARGE Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Flow Cytometry (FACS)

Klon: LARGE-02

Produktdetails anti-LARGE Antikörper

Bindungsspezifität: AA 35-142

Spezifität: This antibody recognizes human LARGE1, a glycosyltransferase localizing mainly to the Golgi apparatus. Crossreactivity with LARGE2 was not determined.

Aufreinigung: Protein-A affinity chromatography (> 95% pure by SDS-PAGE)

Immunogen: Recombinant fragment of human LARGE1 (amino acids 35-142)

Isotyp: IgG2b

Anwendungsinformationen

Applikationshinweise: Flow cytometry. Western blot.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: 95 % pure by SDS-PAGE) Buffer System: Phosphate buffered saline (PBS) Preservatives: 15 mM sodium azide, approx. pH 7.4

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store undiluted at 2-8°C. DO NOT FREEZE! Shelf life: one year from despatch.

Haltbarkeit: 12 months

Details zu LARGE

Target: LARGE (Like-Glycosyltransferase (LARGE))

Andere Bezeichnung: large

Hintergrund: LARGE1 serves as a glycosyltransferase which participates in glycosylation of the muscle membrane protein alpha-dystroglycan. Mutations of LARGE1 lead to hypoglycosylation of alpha-dystroglycan and cause congenital muscular dystrophy (MDC1D) associated with severe mental retardation. Altered alpha-dystroglycan glycosylation may also play a role in cancer, as hypoglycosylation of the protein and loss of laminin binding have been demonstrated in invasive carcinoma cells.

UniProt: O95461