TBX2 Antikörper (AA 554-702)

Produktnummer ABIN5541456

Der Maus Monoklonal Anti-TBX2-Antikörper wurde für WB, IP und IHC (p) validiert. Er ist geeignet, TBX2 in Proben von Human zu detektieren.

Kurzübersicht für TBX2 Antikörper (AA 554-702) (ABIN5541456)

Target: TBX2 (T-Box 2 (TBX2))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser TBX2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: 4D6

Produktdetails anti-TBX2 Antikörper

Bindungsspezifität: AA 554-702

Aufreinigung: Purified

Immunogen: Derived by fusion of SP2/0 mouse myeloma cells with spleen cells from a BALB/c mouse immunized with a GST fusion protein corresponding to residues 554-702 of Human TBX2.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Western blot. Immunoprecipitation. Immunohistochemistry on Paraffin Sections.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Buffer System: PBS Preservatives: 0.09 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.

Haltbarkeit: 12 months

Details zu TBX2

Target: TBX2 (T-Box 2 (TBX2))

Andere Bezeichnung: tbx2

Hintergrund: T-box transcription factor TBX2 is a protein that in humans is encoded by the TBX2 gene and with subcellulair location in the nucleus. This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene product is the human homolog of mouse Tbx2, and shares strong sequence similarity with Drosophila omb protein. Expression studies indicate that this gene may have a potential role in tumorigenesis as an immortalizing agent. Transcript heterogeneity due to alternative polyadenylation has been noted for this gene. In melanocytic cell types, expression of the T-box 2 gene is regulated by the Microphthalmia-associated transcription factor The oncogene TBX2 is a cooperating factor in transformation of pocket protein deficient MEFs. TBX2 downregulates the p53/p21CIP1 pathway both in wild-type and pocket protein deficient MEFs. Tissue specificity: expressed primarily in adult in kidney, lung, and placenta. Weak expression in heart and ovary.

UniProt: Q13207

Pathways: p53 Signalweg