CCRL2 Antikörper

Produktnummer ABIN5541108

Der Maus Monoklonal Anti-CCRL2-Antikörper wurde für IHC (p) validiert. Er ist geeignet, CCRL2 in Proben von Human zu detektieren.

Kurzübersicht für CCRL2 Antikörper (ABIN5541108)

Target: CCRL2 (Chemokine (C-C Motif) Receptor-Like 2 (CCRL2))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CCRL2 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: 1B2

Produktdetails anti-CCRL2 Antikörper

Spezifität: This antibody detects human CCRL2.

Aufreinigung: Protein G

Immunogen: DNA vaccine

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise: Immunohistochemistry on paraffin sections: 4-8 μg/mL (1/50-1/100). Positive control: Human placenta.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: Phosphate buffered saline pH 7.2 (PBS) Preservatives: 0.1 % Kathon Stabilizers: 5 mg/mL bovine serum albumin (BSA)

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store lyophilized at 2-8°C for 6 month or at -20°C long term. After reconstitution store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C long term. Avoid repeated freezing and thawing. Shelf life: one year from despatch.

Haltbarkeit: 12 months

Details zu CCRL2

Target: CCRL2 (Chemokine (C-C Motif) Receptor-Like 2 (CCRL2))

Andere Bezeichnung: ccrl2,ccr11

Hintergrund: Lipopolysaccharide-inducible CC chemokine receptor (LCCR), or CCRL2 is a 344 amino acid protein that belongs to the G - protein coupled receptor 1 family, with a potential glycosylation site and one disulfide bond. CCRL2 is e xp ressed abundantly in immunal tissues such as spleen, fetal liver, lymph node and bone marrow, but also in lung and heart. CCRL2 is e xpressed in almost all hematopoietic cells including monocytes, macrophages, PMNs, T - cells (both CD4+ and CD8+), monocyte - de rived iDCs, NK cells, and CD34+ progenitor cells, and also on glial cells and mast cells at inflammatory sites. It has been reported to be up - regulated on synovial neutrophils of rheumatoid arthritis patients. Unlike other known G - protein coupled receptors, binding of an agonist such as CCL5 or CCL19 does not induce signal transduction through CCRL2. Rather, the ligand is absorbed after binding, and the receptor recycled, thus reducing the local ligand concentration. The leukocyte chemoattractant chemerin is a ligand for CCRL2 as well, but rather than being recycled, the complex seems to promote bridging to the chemerin receptor on nearby cells.

UniProt: O00421