CMKLR1 Antikörper

Produktnummer ABIN5541107

Dieses Maus Monoklonal-Antikörper erkennt spezifisch CMKLR1 in IHC (p). Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für CMKLR1 Antikörper (ABIN5541107)

Target: CMKLR1 (Chemokine-Like Receptor 1 (CMKLR1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CMKLR1 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: 1A7

Produktdetails anti-CMKLR1 Antikörper

Spezifität: This antbody detects Chemerin receptor.

Aufreinigung: Affinity Chromatography on Protein G

Immunogen: DNA vaccine

Isotyp: IgG2b

Anwendungsinformationen

Applikationshinweise: Immunohistochemistry on paraffin sections: 1 μg/mL (1/200) predigestion w ith proteinase K required.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: Phosphate buffered saline pH 7.2 (PBS) Preservatives: 0.1 % Kathon Stabilizers: 5 mg/mL bovine serum albumin

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store lyophilized at 2-8°C for 6 month or at -20°C long term. After reconstitution store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C long term. Avoid repeated freezing and thawing. Shelf life: one year from despatch.

Haltbarkeit: 12 months

Details zu CMKLR1

Target: CMKLR1 (Chemokine-Like Receptor 1 (CMKLR1))

Andere Bezeichnung: chemokine receptor-like 1

Hintergrund: G - protein coupled receptor ChemR23 is a 373 amino acid protein that belongs to the G - protein coupled receptor 1 family, with two potential glycosylation sites and one disulfide bond. The ligand Chemerin (or retinoic acid receptor responder protein 2 , RARRES2) is a 14 kDa protein found to stimulate chemotaxis of dendritic cells , monocytes / macrophages and natural killer cells to the site of inflammation. Accordingly, there is abundant expression of the receptor on these cells. ChemR23 is prominently expressed in developing osseous and cartilaginous tissue, as well as in tissues associated with hematopoietic and immune function including spleen, thymus, appendix, lymph node, bone marrow and fetal liver. The rece ptor is also found in adult parathyroid glands, in the cardiovascular system, brain, kidney, gastrointestinal and myeloid tissues and on endothelial cells. ChemR23 a cts as a cor eceptor for several SIV strains, as well as a primary HIV - 1 strain.

UniProt: Q99788