CBX1 Antikörper

Produktnummer ABIN5540983

Dieses Anti-CBX1-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von CBX1 in IHC (p). Geeignet für Human, Maus und Schwein.

Kurzübersicht für CBX1 Antikörper (ABIN5540983)

Target: CBX1 (Chromobox Homolog 1 (CBX1))

Reaktivität: Human, Maus, Schwein

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CBX1 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: 1MOD-1A9

Produktdetails anti-CBX1 Antikörper

Spezifität: This antibody detects HP1β.

Aufreinigung: Purified

Immunogen: Recombinant mouse HP1beta

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Immunohistochemistry on paraffin sections: 4 μg/mL (1:50). Microwave pretreatment in citrate buffer is recommended for antigen retrieval. Suggested Positive control: Human / Swine brain cortex.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: Buffer System: Phosphate buffered saline pH 7.2 (PBS) Preservatives: 0.01 % Kathon Stabilizers: 5 mg/mL bovine serum albumin (BSA)

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store lyophilized at 2-8°C for 6 month or at -20°C long term. After reconstitution store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C long term. Avoid repeated freezing and thawing. Shelf life: one year from despatch.

Haltbarkeit: 12 months

Details zu CBX1

Target: CBX1 (Chromobox Homolog 1 (CBX1))

Andere Bezeichnung: cbx1

Hintergrund: Heterochromatin Protein 1 (HP1) (Chromobox Homolog, CBX) includes three isoforms in mammals, designated α, β, and γ. HP1 proteins are approximately 25 kDa in size. They are highly conserved adapter proteins with important regulatory functions in the cell nucleus. These functions include notably gene silencing by heterochromatin formation. HP1 proteins are fundamental units of heterochromatin packaging that are enriched at the centromeres and telomeres of nearly all Eukaryotic chromosomes. HP1 β and γ also localize to euchromatic sites in the genome. Members of the HP1 family are characterized by an N-terminal chromodomain and a C- terminal chromoshadow domain, separated by a Hinge region. Chromodomain and chromoshadow domain establish secondary interactions with a large number of other proteins. HP1 proteins are subject to multiple types of post - translational modifications, including phosphorylation, acetylation, methylation, ubiquitination and sumoylation, suggesting multiple means of regulation.

UniProt: P83916