ICT1 Antikörper (AA 30-206)

Produktnummer ABIN5540729

Dieses Maus Monoklonal-Antikörper erkennt spezifisch ICT1 in WB, FACS und EIA. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für ICT1 Antikörper (AA 30-206) (ABIN5540729)

Target: ICT1 (Immature Colon Carcinoma Transcript 1 (ICT1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser ICT1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Flow Cytometry (FACS), Enzyme Immunoassay (EIA)

Klon: AT1E9

Produktdetails anti-ICT1 Antikörper

Bindungsspezifität: AA 30-206

Spezifität: This antibody detects ICT1 at aa30-206.

Aufreinigung: Protein-A affinity chromatography

Immunogen: Recombinant human ICT1 (30-206aa) purified from E. coli

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: ELISA. Western blot: Recommended starting dilution is 1:1000. Flow cytometry.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS, pH 7.4 containing 0.02 % Sodium Azide and 10 % Glycerol

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store undiluted at 2-8°C for up to two weeks or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.

Haltbarkeit: 12 months

Details zu ICT1

Target: ICT1 (Immature Colon Carcinoma Transcript 1 (ICT1))

Andere Bezeichnung: ict1,ds1

Hintergrund: Peptidyl-tRNA hydrolase ICT1 acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. The adult colon epithelium contains 3 differentiated cell types that arise from a multipotent stem cell. Deviation from the normal maturation pathway by neoplastic transformation is thought to initiate in stem cells or their early descendants. This neoplastic-induced deviation is marked by a change in expression of several mRNAs. ICT1 is a member of the prokaryotic/mitochondrial release factor family whose expression is downregulated over 4 fold upon colon stem cell differentiation. This downregulation of ICT1 could lead to its use as a marker for detection of colon carcinomas.

UniProt: Q14197