Syndecan 2 Antikörper

Produktnummer ABIN5540684

Dieses Maus Monoklonal-Antikörper erkennt spezifisch Syndecan 2 in WB, EIA und IHC (fro). Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für Syndecan 2 Antikörper (ABIN5540684)

Target: Syndecan 2 (SDC2)

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Syndecan 2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA), Immunohistochemistry (Frozen Sections) (IHC (fro))

Klon: 2E2-B5

Produktdetails anti-Syndecan 2 Antikörper

Spezifität: This Monoclonal antibody is specific for a core protein epitope of a Human small basement membrane Heparan Sulfate Proteoglycan (HS-PG). AM20231PU recognizes an epitope different from that recognized by clones 1F10/B8 (Cat.No AM02102PU) and 2H7/G11 (Cat.-No AM02103PU). Species: Human.

Aufreinigung: Protein G Chromatography

Immunogen: Purified Human small basement membrane Heparan Sulfate Proteoglycan (HS-PG)

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: ELISA (less than 1 μg/mL). Western blot (1 μg/mL). Immunohistochemistry (1 μg/mL)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: 50 mM TRIS pH 7.4

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store lyophilized at 2-8°C for 6 months or at -20°C long term. After reconstitution store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C long term. Avoid repeated freezing and thawing. Shelf life: one year from despatch.

Haltbarkeit: 12 months

Details zu Syndecan 2

Target: Syndecan 2 (SDC2)

Andere Bezeichnung: hspg1,syndecan-2

Hintergrund: The principal molecular structure of basement membranes has been elucidated during the past two decades and it was shown that for example in the glomerular basement membrane (GBM) HS-PG are responsible for the selective filtration process. Removal of HS-PG will lead to proteinuria. Whereas previously perlecan was the only known basement membrane HS-PG, there is now evidence that (at least two) other basement membrane HS-PG do exist: Agrin, originally discovered as an important component of the neuromuscular junction and a novel small HS-PG, that was isolated from human aorta and kidney. This HS-PG, with a molecular weight of 80-200 kDa (aorta) and 30-160 kDa (kidney) and a core protein size of 24 kDa or 22 kDa, respectively, was localized by immunohistoche-mistry to the basement membrane. Amino acid sequence ana-lysis of tryptic peptides indicate, that this small HS-PG is clearly distinct from perlecan and agrin.

UniProt: P34741

Pathways: Glycosaminoglycan Metabolic Process