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ERAS Antikörper (N-Term)

ERAS Reaktivität: Human WB, IF, IHC (p), FACS Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN5534212
  • Target Alle ERAS Antikörper anzeigen
    ERAS (ES cell expressed Ras (ERAS))
    Bindungsspezifität
    • 19
    • 15
    • 8
    • 7
    • 7
    • 6
    • 6
    • 5
    • 5
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 13-42, N-Term
    Reaktivität
    • 67
    • 11
    • 8
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    Human
    Wirt
    • 69
    • 2
    Kaninchen
    Klonalität
    • 71
    Polyklonal
    Konjugat
    • 30
    • 8
    • 7
    • 7
    • 4
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser ERAS Antikörper ist unkonjugiert
    Applikation
    • 52
    • 42
    • 32
    • 21
    • 14
    • 13
    • 13
    • 10
    • 7
    • 3
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)
    Aufreinigung
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
    Immunogen
    This ERAS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 13-42 amino acids from the N-terminal region of human ERAS.
    Isotyp
    Ig Fraction
    Top Product
    Discover our top product ERAS Primärantikörper
  • Applikationshinweise
    For WB starting dilution is: 1:1000

    For IHC-P starting dilution is: 1:50

    For IF starting dilution is: 1:10~50

    For FACS starting dilution is: 1:10~50
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    2 mg/mL
    Buffer
    Supplied in PBS with 0.09 % (W/V) sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
  • Target
    ERAS (ES cell expressed Ras (ERAS))
    Andere Bezeichnung
    ERAS (ERAS Produkte)
    Synonyme
    HRAS2 antikoerper, HRASP antikoerper, HRasp antikoerper, Ha-Ras2 antikoerper, ecat5 antikoerper, ES cell expressed Ras antikoerper, ES cell-expressed Ras antikoerper, ERAS antikoerper, Eras antikoerper
    Hintergrund
    Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Point mutations of several amino acids of human RAS, including gly12, ala59, or glu63, render the protein constitutively active. Embryonic stem cell-expressed Ras (ERAS) has serine, alanine, and asparagine at the positions corresponding to gly12, ala59, and glu63 of human RAS, suggesting that it is constitutively active.The PI3K (phosphoinositide 3-kinase) pathway is important for proliferation, survival and maintenance of pluripotency in ES cells. The PI3K pathway is activated by growth factors and cytokines including insulin and leukaemia inhibitory factor. In addition to these exogenous factors, the PI3K pathway is endogenously activated by the constitutively active Ras family protein ERas (ES cell-expressed Ras). ERas null ES cells maintained pluripotency but show significantly reduced growth and tumorigenicity, which can be rescued by expression of ERas cDNA or by activated phosphatidylinositol 3-hydroxykinase. The transforming oncogene ERAS appears to be important in the tumor-like growth properties of ES cells.
    Molekulargewicht
    25 kDa
    Gen-ID
    3266
    UniProt
    Q7Z444
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