PRDM6 Antikörper (N-Term)

Produktnummer ABIN5531881

Dieses Anti-PRDM6-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von PRDM6 in WB. Geeignet für Human.

Kurzübersicht für PRDM6 Antikörper (N-Term) (ABIN5531881)

Target: PRDM6 (PR Domain Containing 6 (PRDM6))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PRDM6 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-PRDM6 Antikörper

Bindungsspezifität: AA 44-72, N-Term

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This PRDM6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 44-72 amino acids from the N-terminal region of human PRDM6.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: For WB starting dilution is: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.35 mg/mL

Buffer: Supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu PRDM6

Target: PRDM6 (PR Domain Containing 6 (PRDM6))

Andere Bezeichnung: PRDM6

Hintergrund: Putative histone methyltransferase that acts as a transcriptional repressor of smooth muscle gene expression. Promotes the transition from differentiated to proliferative smooth muscle by suppressing differentiation and maintaining the proliferative potential of vascular smooth muscle cells. Also plays a role in endothelial cells by inhibiting endothelial cell proliferation, survival and differentiation. It is unclear whether it has histone methyltransferase activity in vivo. According to some authors, it does not act as a histone methyltransferase by itself and represses transcription by recruiting EHMT2/G9a. According to others, it possesses histone methyltransferase activity when associated with other proteins and specifically methylates 'Lys-20' of histone H4 in vitro. 'Lys-20' methylation represents a specific tag for epigenetic transcriptional repression (By similarity).

Molekulargewicht: 64 kDa

Gen-ID: 93166

UniProt: Q9NQX0

Pathways: Regulation of Muscle Cell Differentiation