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MMP16 Antikörper (AA 120-296)

MMP16 Reaktivität: Human, Maus, Ratte WB, IHC, ELISA, FACS, IF, ICC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN5519039
  • Target Alle MMP16 Antikörper anzeigen
    MMP16 (Matrix Metallopeptidase 16 (Membrane-inserted) (MMP16))
    Bindungsspezifität
    • 15
    • 8
    • 8
    • 8
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 120-296
    Reaktivität
    • 55
    • 30
    • 15
    • 7
    • 7
    • 7
    • 6
    • 5
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Human, Maus, Ratte
    Wirt
    • 53
    • 2
    Kaninchen
    Klonalität
    • 53
    • 2
    Polyklonal
    Konjugat
    • 18
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser MMP16 Antikörper ist unkonjugiert
    Applikation
    • 37
    • 22
    • 19
    • 17
    • 12
    • 12
    • 8
    • 4
    • 3
    • 2
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Flow Cytometry (FACS), Immunofluorescence (IF), Immunocytochemistry (ICC)
    Verwendungszweck
    Anti-MMP16 Antibody Picoband®
    Kreuzreaktivität (Details)
    No cross-reactivity with other proteins.
    Produktmerkmale
    Anti-MMP16 Antibody Picoband® (ABIN5519039). Tested in ELISA, Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
    Aufreinigung
    Immunogen affinity purified.
    Immunogen
    E. coli-derived human MMP16 recombinant protein (Position: Y120-I296).
    Isotyp
    IgG
    Top Product
    Discover our top product MMP16 Primärantikörper
  • Applikationshinweise
    Western blot, 0.1-0.5 μg/mL
    Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL
    Immunocytochemistry/Immunofluorescence, 2 μg/mL
    Flow Cytometry (Fixed), 1-3 μg/1x106 cells
    ELISA, 0.1-0.5 μg/mL
    1. Sato, H., Tanaka, M., Takino, T., Inoue, M., Seiki, M. : Assignment of the human genes for membrane-type-1, -2, and -3 matrix metalloproteinases (MMP14, MMP15, and MMP16) to 14q12.2, 16q12.2-q21, and 8q21, respectively, by in situ hybridization. Genomics 39: 412-413, 1997. 2. Takino, T., Sato, H., Shinagawa, A., Seiki, M. : Identification of the second membrane-type matrix metalloproteinase (MT-MMP-2) gene from a human placenta cDNA library: MT-MMPs form a unique membrane-type subclass in the MMP family. J. Biol. Chem. 270: 23013-23020, 1995.
    Kommentare

    We recommend Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ABIN921124) for Western blot, and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (SV0002-1) for IHC(P).

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    Konzentration
    500 μg/mL
    Buffer
    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
  • Xue, Wu, Chen, Luo: "MT3-MMP down-regulation promotes tumorigenesis and correlates to poor prognosis in esophageal squamous cell carcinoma." in: Cancer medicine, Vol. 5, Issue 9, pp. 2459-68, (2017) (PubMed).

    Wang, Li, Wu, Wu, Li, Yang, Chen, Xie, Huang, Du, Zhou: "miR-132 can inhibit glioma cells invasion and migration by target MMP16 in vitro." in: OncoTargets and therapy, Vol. 8, pp. 3211-8, (2015) (PubMed).

  • Target
    MMP16 (Matrix Metallopeptidase 16 (Membrane-inserted) (MMP16))
    Andere Bezeichnung
    MMP16 (MMP16 Produkte)
    Hintergrund

    Synonyms: Matrix metalloproteinase-16, MMP-16, 3.4.24.-, MMP-X2, Membrane-type matrix metalloproteinase 3, MT-MMP 3, MTMMP3, Membrane-type-3 matrix metalloproteinase, MT3-MMP, MT3MMP, MMP16, MMPX2,

    Tissue Specificity: Expressed in heart, brain, placenta, ovary and small intestine. Isoform Short is found in the ovary.

    Background: The matrix metalloproteinase 16 (MMP16) protein consists of 604 amino acids and has a characteristic MMP domain structure, which gene is mapped on human chromosome 8q21. Additionally, MMP16 has a C-terminal extension containing a potential transmembrane domain, similar to MMP14, MMP15, and MMP17. Furthermore, it is membrane-bound and is a member of the membrane-type MMPs that are a subclass in the MMP family since the other members lack a C-terminal transmembrane domain and are secreted as soluble forms. MMP16 is expressed as a 12-kb transcript in brain, placenta, heart, and some carcinoma cell lines, but is not detectably expressed in lung, kidney, liver, spleen, and muscle.

    Molekulargewicht
    53 kDa
    Gen-ID
    4325
    UniProt
    P51512
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