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CCL20 Antikörper (AA 28-97)

Dieses Anti-CCL20-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von CCL20 in WB und ELISA. Geeignet für Maus und Ratte.
Produktnummer ABIN5518973

Kurzübersicht für CCL20 Antikörper (AA 28-97) (ABIN5518973)

Target

Alle CCL20 Antikörper anzeigen
CCL20 (Chemokine (C-C Motif) Ligand 20 (CCL20))

Reaktivität

  • 80
  • 40
  • 14
  • 3
  • 2
  • 2
  • 1
  • 1
  • 1
Maus, Ratte

Wirt

  • 62
  • 38
  • 4
  • 1
  • 1
Kaninchen

Klonalität

  • 63
  • 43
Polyklonal

Konjugat

  • 58
  • 13
  • 7
  • 4
  • 4
  • 3
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser CCL20 Antikörper ist unkonjugiert

Applikation

  • 74
  • 49
  • 38
  • 34
  • 25
  • 13
  • 13
  • 10
  • 5
  • 5
  • 4
  • 4
  • 3
  • 3
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
Western Blotting (WB), ELISA
  • Bindungsspezifität

    • 15
    • 15
    • 5
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 28-97

    Verwendungszweck

    Anti-MIP-3 Alpha/CCL20 Antibody Picoband®

    Kreuzreaktivität (Details)

    No cross-reactivity with other proteins.

    Produktmerkmale

    Anti-MIP-3 Alpha/CCL20 Antibody Picoband® (ABIN5518973). Tested in ELISA, WB applications. This antibody reacts with Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

    Aufreinigung

    Immunogen affinity purified.

    Immunogen

    E. coli-derived mouse MIP-3 Alpha/CCL20 recombinant protein (Position: A28-M97).

    Isotyp

    IgG
  • Applikationshinweise

    Western blot, 0.1-0.5 μg/mL
    ELISA (Cap), 1-5 μg/mL
    1. Harant, H., Eldershaw, S. A, Lindley, I. J. Human macrophage inflammatory protein-3-alpha/CCL20/LARC/EXODUS/SCYA20 is transcriptionally upregulated by tumor necrosis factor-alpha via a non-standard NF-kappa-B site. FEBS Lett. 509: 439-445, 2001. 2. Nelson, R. T., Boyd, J., Gladue, R. P., Paradis, T., Thomas, R., Cunningham, A. C., Lira, P., Brissette, W. H., Hayes, L., Hames, L. M., Neote, K. S., McColl, S. R. Genomic organization of the CC chemokine MIP-3-alpha/CCL20/LARC/EXODUS/SCYA20, showing gene structure, splice variants, and chromosome localization. Genomics 73: 28-37, 2001.

    Kommentare

    We recommend Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ABIN921124) for Western blot.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Lyophilized

    Rekonstitution

    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

    Konzentration

    500 μg/mL

    Buffer

    Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
  • Target

    CCL20 (Chemokine (C-C Motif) Ligand 20 (CCL20))

    Andere Bezeichnung

    Ccl20

    Hintergrund

    Synonyms: C-C motif chemokine 20, Beta-chemokine exodus-1, CC chemokine LARC, CC chemokine ST38, Liver and activation-regulated chemokine, Macrophage inflammatory protein 3 alpha, MIP-3-alpha, Small-inducible cytokine A20, Ccl20, Larc, Scya20,

    Tissue Specificity: Thymic medulla (at protein level). Prominently expressed in the small intestine, colon and appendix. Also found in thymus, spleen, lymph node and lung. The long form might be dominant in intestinal, and the short form in lymphoid tissues. Expressed by IL17 producing helper T-cells (Th17).

    Background: Macrophage Inflammatory Protein 3alpha (MIP3alpha), also called Chemokine, cc motif, ligand 20 (CCL20). The MIP-3alpha/CCL20 gene was cloned and sequenced, revealing a four exon, three intron structure, and was localized by FISH analysis to 2q35-q36. MIP3alpha is predominantly expressed in lymph nodes, appendix, PBL, fetal liver, fetal lung and several cell lines. MIP3alpha/CCL20 and its receptor CCR6 are markedly up-regulated in psoriasis, and they may play a role in the recruitment of T cells to lesional psoriatic skin. And Alanine MIP-3alpha and Serine MIP-3alpha, the two forms of MIP3alpha, that differ by one amino acid at the predicted signal peptide cleavage site. Both of them were chemically synthesized and tested for biological activity. And both flu antigen plus IL-2-activated CD4 (+) and CD8 (+) T lymphoblasts and cord blood-derived dendritic cells responded to Ser and Ala MIP-3alpha.

    Molekulargewicht

    14 kDa

    Gen-ID

    20297

    UniProt

    O89093

    Pathways

    Phosphorylierungen bei SARS-CoV-2 Infektion
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