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PPIA Antikörper (AA 116-165)

PPIA Reaktivität: Human, Maus, Ratte WB, IHC, ICC, FACS, IF, IHC (fro) Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN5518864
  • Target Alle PPIA Antikörper anzeigen
    PPIA (Peptidylprolyl Isomerase A (Cyclophilin A) (PPIA))
    Bindungsspezifität
    • 15
    • 15
    • 11
    • 9
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    AA 116-165
    Reaktivität
    • 82
    • 54
    • 44
    • 8
    • 5
    • 5
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    Human, Maus, Ratte
    Wirt
    • 89
    • 5
    • 3
    • 1
    Kaninchen
    Klonalität
    • 83
    • 15
    Polyklonal
    Konjugat
    • 36
    • 15
    • 12
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser PPIA Antikörper ist unkonjugiert
    Applikation
    • 68
    • 29
    • 25
    • 19
    • 14
    • 12
    • 12
    • 9
    • 9
    • 5
    • 3
    • 3
    • 2
    • 2
    Western Blotting (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Verwendungszweck
    Anti-Cyclophilin A/PPIA Antibody Picoband®
    Kreuzreaktivität (Details)
    No cross-reactivity with other proteins
    Produktmerkmale
    Anti-Cyclophilin A/PPIA Antibody Picoband® (ABIN5518864). Tested in Flow Cytometry, IF, IHC, IHC-F, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
    Aufreinigung
    Immunogen affinity purified.
    Immunogen
    E.coli-derived human Cyclophilin A recombinant protein (Position: T116-E165). Human Cyclophilin A shares 98% and 95.9% amino acid (aa) sequence identity with mouse and rat Cyclophilin A, respectively.
    Isotyp
    IgG
    Top Product
    Discover our top product PPIA Primärantikörper
  • Applikationshinweise
    Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human, Mouse, Rat
    Western blot, 0.1-0.5 μg/mL, Human, Mouse, Rat
    Immunohistochemistry (Frozen Section), 0.5-1 μg/mL, Human
    Immunocytochemistry/Immunofluorescence, 2 μg/mL, Human
    Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human1. Luban, J., Bossolt, K. L., Franke, E. K., Kalpana, G. V., Goff, S. P.Human immunodeficiency virus type 1 gag protein binds to Cyclophilin A and B.Cell 73: 1067-1078, 1993. 2. Manel, N., Hogstad, B., Wang, Y., Levy, D. E., Unutmaz, D., Littman, D. R.A cryptic sensor for HIV-1 activates antiviral innate immunity in dendritic cells.Nature 467: 214-217, 2010. Note: Erratum: Nature 470: 424 only, 2011. 3. Willenbrink, W., Halaschek, J., Schuffenhauer, S., Kunz, J., Steinkasserer, A. Cyclophilin A, the major intracellular receptor for the immunosuppressant cyclosporin A, maps to chromosome 7p11.2-p13: four pseudogenes map to chromosomes 3, 10, 14, and 18.Genomics 28: 101-104, 1995.
    Kommentare

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    Konzentration
    500 μg/mL
    Buffer
    Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
  • Target
    PPIA (Peptidylprolyl Isomerase A (Cyclophilin A) (PPIA))
    Andere Bezeichnung
    PPIA (PPIA Produkte)
    Hintergrund

    Synonyms: Peptidyl-prolyl cis-trans isomerase A,PPIase A,5.2.1.8,Cyclophilin A,Cyclosporin A-binding protein,Rotamase A,Peptidyl-prolyl cis-trans isomerase A, N-terminally processed,PPIA,CYPA,

    Tissue Specificity: Widely expressed, with highest levels in kidney and testis. Expressed by activated CD4+ T-cells during the development of helper T-cells responses.

    Background: Cyclophilin A (PPIA), Peptidylprolyl isomerase A, is an enzyme that in humans is encoded by the PPIA gene. Using chromosome 7 and chromosome 10 deletion hybrid panels, the PPIA coding gene is localized to 7p13-p11.2. This gene encodes a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. Cyclophilin A is also a member of the immunophilin class of proteins that all possess peptidyl-prolyl cis/trans isomerase activity and are believed to be involved in protein folding and/or intracellular protein transport. And Cyclophilin A binds to the Gag protein of human immunodeficiency virus type 1 (HIV-1). Additionally, Cyclophilin A may have an essential function in HIV-1 replication.may have an essential function in HIV-1 replication.

    Molekulargewicht
    185 kDa
    Gen-ID
    5478
    UniProt
    P62937
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