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KRT8 Antikörper (AA 107-325)

Dieses Anti-KRT8-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von KRT8 in WB und IHC. Geeignet für Human, Ratte und Maus.
Produktnummer ABIN5518853

Kurzübersicht für KRT8 Antikörper (AA 107-325) (ABIN5518853)

Target

Alle KRT8 Antikörper anzeigen
KRT8 (Keratin 8 (KRT8))

Reaktivität

  • 314
  • 88
  • 77
  • 67
  • 65
  • 63
  • 62
  • 16
  • 14
  • 10
  • 8
  • 5
  • 4
  • 3
  • 2
  • 1
  • 1
  • 1
Human, Ratte, Maus

Wirt

  • 169
  • 162
  • 3
Kaninchen

Klonalität

  • 185
  • 146
  • 1
Polyklonal

Konjugat

  • 172
  • 27
  • 17
  • 12
  • 9
  • 8
  • 8
  • 8
  • 8
  • 8
  • 8
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser KRT8 Antikörper ist unkonjugiert

Applikation

  • 239
  • 175
  • 124
  • 89
  • 71
  • 49
  • 48
  • 42
  • 41
  • 40
  • 37
  • 29
  • 22
  • 5
  • 5
  • 4
  • 4
  • 2
  • 2
  • 2
  • 1
  • 1
Western Blotting (WB), Immunohistochemistry (IHC)
  • Bindungsspezifität

    • 23
    • 16
    • 13
    • 11
    • 10
    • 8
    • 6
    • 6
    • 5
    • 5
    • 5
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 107-325

    Verwendungszweck

    Anti-Cytokeratin 8/KRT8 Antibody Picoband®

    Kreuzreaktivität (Details)

    No cross-reactivity with other proteins

    Produktmerkmale

    Anti-Cytokeratin 8/KRT8 Antibody Picoband® (ABIN5518853). Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

    Aufreinigung

    Immunogen affinity purified.

    Immunogen

    E.coli-derived human Cytokeratin 8 recombinant protein (Position: D107-K325). Human Cytokeratin 8 shares 95.4% and 94.5% amino acid (aa) sequence identity with mouse and rat Cytokeratin 8, respectively.

    Isotyp

    IgG
  • Applikationshinweise

    Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human, Mouse, Rat
    Western blot, 0.1-0.5 μg/mL, Human, Mouse, Rat
    1. He, T., Stepulak, A., Holmstrom, T. H., Omary, M. B., Eriksson, J. E. : The intermediate filament protein kinase 8 is a novel cytoplasmic substrate for c-Jun N-terminal kinase. J. Biol. Chem. 277: 10767-10774, 2002. 2. Krauss, S., Franke, W. W. : Organization and sequence of the human gene encoding cytokeratin 8. Gene 86: 241-249, 1990. 3. Yamamoto, R., Kao, L.-C., McKnight, C. E., Strauss, J. F., III : Cloning and sequence of cDNA for human placental cytokeratin 8: regulation of the mRNA in trophoblastic cells by cAMP. Molec. Endocr. 4: 370-374, 1990.

    Kommentare

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Lyophilized

    Rekonstitution

    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

    Konzentration

    500 μg/mL

    Buffer

    Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
  • Target

    KRT8 (Keratin 8 (KRT8))

    Andere Bezeichnung

    KRT8

    Hintergrund

    Synonyms: Keratin, type II cytoskeletal 8,Cytokeratin-8,CK-8,Keratin-8,K8,Type-II keratin Kb8,KRT8,CYK8,

    Tissue Specificity: Observed in muscle fibers accumulating in the costameres of myoplasm at the sarcolemma membrane in structures that contain dystrophin and spectrin. Expressed in gingival mucosa and hard palate of the oral cavity. .

    Background: Keratin, type II cytoskeletal 8, also known as cytokeratin-8 (CK-8) or keratin-8 (K8) is a keratin protein that is encoded in humans by the KRT8 gene. This gene is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. The product of this gene typically dimerizes with keratin 18 to form an intermediate filament in simple single-layered epithelial cells. This protein plays a role in maintaining cellular structural integrity and also functions in signal transduction and cellular differentiation. Mutations in this gene cause cryptogenic cirrhosis. Alternatively spliced transcript variants have been found for this gene.

    Molekulargewicht

    54 kDa, 56 kDa

    Gen-ID

    3856

    UniProt

    P05787
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