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HSD17B4 Antikörper (AA 510-736)

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch HSD17B4 in WB und IHC. Er zeigt eine Reaktivität gegenüber Human, Maus und Ratte.
Produktnummer ABIN5518845

Kurzübersicht für HSD17B4 Antikörper (AA 510-736) (ABIN5518845)

Target

Alle HSD17B4 Antikörper anzeigen
HSD17B4 (Hydroxysteroid (17-Beta) Dehydrogenase 4 (HSD17B4))

Reaktivität

  • 38
  • 24
  • 15
  • 15
  • 8
  • 2
Human, Maus, Ratte

Wirt

  • 50
  • 3
Kaninchen

Klonalität

  • 50
  • 3
Polyklonal

Konjugat

  • 27
  • 3
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser HSD17B4 Antikörper ist unkonjugiert

Applikation

  • 45
  • 17
  • 17
  • 13
  • 13
  • 13
  • 5
  • 5
  • 3
  • 2
  • 1
  • 1
  • 1
Western Blotting (WB), Immunohistochemistry (IHC)
  • Bindungsspezifität

    • 15
    • 7
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 510-736

    Verwendungszweck

    Anti-Hydroxysteroid (17-beta) Dehydrogenase 4/HSD17B4 Antibody Picoband®

    Kreuzreaktivität (Details)

    No cross-reactivity with other proteins

    Produktmerkmale

    Anti-Hydroxysteroid (17-beta) Dehydrogenase 4/HSD17B4 Antibody Picoband® (ABIN5518845). Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

    Aufreinigung

    Immunogen affinity purified.

    Immunogen

    E.coli-derived human HSD17B4 recombinant protein (Position: D510-L736). Human HSD17B4 shares 87.7% and 89% amino acid (aa) sequence identity with mouse and rat HSD17B4, respectively.

    Isotyp

    IgG
  • Applikationshinweise

    Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human
    Western blot, 0.1-0.5 μg/mL, Human, Mouse, Rat
    1. "Entrez Gene: HSD17B4 Hydroxysteroid (17-beta) dehydrogenase 1". 2. Aka JA, Mazumdar M, Chen CQ, Poirier D, Lin SX (Apr 2010). "17beta-hydroxysteroid dehydrogenase type 1 stimulates breast cancer by dihydrotestosterone inactivation in addition to estradiol production".Molecular Endocrinology. 24 (4): 832-45.

    Kommentare

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Lyophilized

    Rekonstitution

    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

    Konzentration

    500 μg/mL

    Buffer

    Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
  • Target

    HSD17B4 (Hydroxysteroid (17-Beta) Dehydrogenase 4 (HSD17B4))

    Andere Bezeichnung

    HSD17B4

    Hintergrund

    Synonyms: Peroxisomal multifunctional enzyme type 2,MFE-2,17-beta-hydroxysteroid dehydrogenase 4,17-beta-HSD 4,D-bifunctional protein,DBP,Multifunctional protein 2,MPF-2,Short chain dehydrogenase/reductase family 8C member 1, (3R)-hydroxyacyl-CoA dehydrogenase,1.1.1.n12,Enoyl-CoA hydratase 2,4.2.1.107,4.2.1.119,3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA hydratase,HSD17B4,EDH17B4, SDR8C1,

    Tissue Specificity: Present in many tissues with highest concentrations in liver, heart, prostate and testis.

    Background: Peroxisomal multifunctional enzyme type 2 is a protein that in humans is encoded by the HSD17B4 gene. The protein encoded by this gene is a bifunctional enzyme that is involved in the peroxisomal beta-oxidation pathway for fatty acids. It also acts as a catalyst for the formation of 3-ketoacyl-CoA intermediates from both straight-chain and 2-methyl-branched-chain fatty acids. Defects in this gene that affect the peroxisomal fatty acid beta-oxidation activity are a cause of D-bifunctional protein deficiency (DBPD). An apparent pseudogene of this gene is present on chromosome 8. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

    Molekulargewicht

    80 kDa

    Gen-ID

    3295

    UniProt

    P51659

    Pathways

    Monocarboxylic Acid Catabolic Process
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