HPSE Antikörper (AA 206-457)

Produktnummer ABIN5518844

Produktdetails anti-HPSE Antikörper

Target: HPSE (Heparanase (HPSE))

Bindungsspezifität: AA 206-457

Reaktivität: Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HPSE Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Verwendungszweck: Rabbit IgG polyclonal antibody for Heparanase(Hpse) detection. Tested with WB in Mouse.

Kreuzreaktivität (Details): No cross reactivity with other proteins.

Produktmerkmale: Rabbit IgG polyclonal antibody for Heparanase(Hpse) detection. Tested with WB in Mouse.
Gene Name: heparanase
Protein Name: Heparanase

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived mouse Heparanase 1 recombinant protein (Position: K206-K457). Mouse Heparanase 1 shares 80.2% and 96.4% amino acid (aa) sequence identity with human and rat Heparanase 1, respectively.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Mouse
Notes: Tested Species: Species with positive results.
Other applications have not been tested. Optimal dilutions should be determined by end users.

Kommentare:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Referenzen für anti-HPSE Antikörper (ABIN5518844)

Qin, Xu, Qi, Guo, Wang, Xu, Qiao, Gu, Niu: "Evaluation of the C-domain of heparanase during AGE-induced macrophage inflammatory response." in: Experimental and therapeutic medicine, Vol. 14, Issue 2, pp. 1017-1022, (2017) (PubMed).

Huining, Yi, Dihong, Yifeng, Man, Ting, Jingting: "Inhibition of choriocarcinoma by Fe3O4-dextran-anti-β-human chorionic gonadotropin nanoparticles containing antisense oligodeoxynucleotide of heparanase." in: International journal of nanomedicine, Vol. 8, pp. 4371-8, (2014) (PubMed).

Details zu HPSE

Target: HPSE (Heparanase (HPSE))

Andere Bezeichnung: Hpse (HPSE Produkte)

Synonyme: im:7144134 antikoerper, hpa antikoerper, hpa1 antikoerper, hpr1 antikoerper, hpse1 antikoerper, hse1 antikoerper, HPSE antikoerper, HPA antikoerper, HPA1 antikoerper, HPR1 antikoerper, HPSE1 antikoerper, HSE1 antikoerper, Hpa antikoerper, Hpr1 antikoerper, Hep antikoerper, heparanase antikoerper, HPSE antikoerper, hpse antikoerper, Hpse antikoerper

Hintergrund: Heparanase, also known as HPSE, is an enzyme that acts both at the cell-surface and within the extracellular matrix to degrade polymeric heparan sulfate molecules into shorter chain length oligosaccharides. Heparanase is an endo-beta-D-glucuronidase capable of cleaving heparan sulfate and has been implicated in inflammation and tumor angiogenesis and metastasis. The successful penetration of the endothelial cell layer that lines the interior surface of blood vessels is an important process in the formation of blood borne tumour metastases. Heparan sulfate proteoglycans are major constituents of this layer and it has been shown that increased metastatic potential corresponds with increased heparanase activity for a number of cell lines.

Synonyms: Heparanase | 3.2.1.166 | Endo-glucoronidase | Heparanase-1 | Hpa1 | Heparanase 8 kDa subunit | Heparanase 50 kDa subunit | HPSE | HEP | HPA | HPA1 | HPR1 | HPSE1 | HSE1 | Q6YGZ1

Gen-ID: 15442

Pathways: Glycosaminoglycan Metabolic Process