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ALDH1A3 Antikörper (AA 37-154)

ALDH1A3 Reaktivität: Human, Maus, Ratte WB, IHC, ICC, IF, FACS, IHC (fro) Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN5518802
  • Target Alle ALDH1A3 Antikörper anzeigen
    ALDH1A3 (Aldehyde Dehydrogenase 1 Family, Member A3 (ALDH1A3))
    Bindungsspezifität
    • 7
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 37-154
    Reaktivität
    • 26
    • 7
    • 1
    • 1
    • 1
    Human, Maus, Ratte
    Wirt
    • 23
    • 3
    Kaninchen
    Klonalität
    • 23
    • 3
    Polyklonal
    Konjugat
    • 18
    • 5
    • 2
    • 1
    Dieser ALDH1A3 Antikörper ist unkonjugiert
    Applikation
    • 22
    • 12
    • 10
    • 8
    • 6
    • 5
    • 2
    • 2
    • 2
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF), Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Verwendungszweck
    Anti-ALDH1A3 Antibody Picoband®
    Kreuzreaktivität (Details)
    No cross-reactivity with other proteins
    Produktmerkmale
    Anti-ALDH1A3 Antibody Picoband® (ABIN5518802). Tested in Flow Cytometry, IF, IHC, IHC-F, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
    Aufreinigung
    Immunogen affinity purified.
    Immunogen
    E.coli-derived human ALDH1A3 recombinant protein (Position: N37-K154). Human ALDH1A3 shares 89% and 87.3% amino acid (aa) sequence identity with mouse and rat ALDH1A3, respectively.
    Isotyp
    IgG
    Top Product
    Discover our top product ALDH1A3 Primärantikörper
  • Applikationshinweise
    Western blot, 0.1-0.5 μg/mL, Human, Mouse, Rat
    Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human, Mouse, Rat
    Immunohistochemistry (Frozen Section), 0.5-1 μg/mL, Human
    Immunocytochemistry/Immunofluorescence, 2 μg/mL, Human
    Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human1. Nishimura M, Yoshitsugu H, Naito S, Hiraoka I (2002). "Evaluation of gene induction of drug-metabolizing enzymes and transporters in primary culture of human hepatocytes using high-sensitivity real-time reverse transcription PCR.". Yakugaku Zasshi. 122 (5): 339-61. 2. Rexer BN, Zheng WL, Ong DE (2001). "Retinoic acid biosynthesis by normal human breast epithelium is via aldehyde dehydrogenase 6, absent in MCF-7 cells.". Cancer Res. 61 (19): 7065-70. 3. Yoshida A, Rzhetsky A, Hsu LC, Chang C (1998). "Human aldehyde dehydrogenase gene family.". Eur. J. Biochem. 251 (3): 549-57.
    Kommentare

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    Konzentration
    500 μg/mL
    Buffer
    Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
  • Target
    ALDH1A3 (Aldehyde Dehydrogenase 1 Family, Member A3 (ALDH1A3))
    Andere Bezeichnung
    ALDH1A3 (ALDH1A3 Produkte)
    Hintergrund

    Synonyms: Aldehyde dehydrogenase family 1 member A3,1.2.1.5,Aldehyde dehydrogenase 6,Retinaldehyde dehydrogenase 3,RALDH-3,RalDH3,ALDH1A3,ALDH6,

    Tissue Specificity: Expressed at low levels in many tissues and at higher levels in salivary gland, stomach, and kidney.

    Background: Aldehyde dehydrogenase 1 family, member A3, also known as ALDH1A3 or retinaldehyde dehydrogenase 3 (RALDH3), is an enzyme that in humans is encoded by the ALDH1A3 gene. Aldehyde dehydrogenase isozymes are thought to play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. The enzyme encoded by this gene uses retinal as a substrate, either in a free or a cellular retinol-binding protein form. Mutations in this gene have been associated with microphthalmia, isolated 8, and expression changes have also been detected in tumor cells. Alternative splicing results in multiple transcript variants.

    Molekulargewicht
    56 kDa
    Gen-ID
    220
    UniProt
    P47895
    Pathways
    Retinoic Acid Receptor Signaling Pathway
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