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ALDH1A3 Antikörper (AA 37-154)

Dieses Anti-ALDH1A3-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von ALDH1A3 in WB, IHC, ICC, IF, FACS und IHC (fro). Geeignet für Human, Maus und Ratte.
Produktnummer ABIN5518802

Kurzübersicht für ALDH1A3 Antikörper (AA 37-154) (ABIN5518802)

Target

Alle ALDH1A3 Antikörper anzeigen
ALDH1A3 (Aldehyde Dehydrogenase 1 Family, Member A3 (ALDH1A3))

Reaktivität

  • 26
  • 7
  • 1
  • 1
  • 1
Human, Maus, Ratte

Wirt

  • 23
  • 3
Kaninchen

Klonalität

  • 23
  • 3
Polyklonal

Konjugat

  • 18
  • 5
  • 2
  • 1
Dieser ALDH1A3 Antikörper ist unkonjugiert

Applikation

  • 22
  • 12
  • 10
  • 8
  • 6
  • 5
  • 2
  • 2
  • 2
  • 1
Western Blotting (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF), Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro))
  • Bindungsspezifität

    • 7
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 37-154

    Verwendungszweck

    Anti-ALDH1A3 Antibody Picoband®

    Kreuzreaktivität (Details)

    No cross-reactivity with other proteins

    Produktmerkmale

    Anti-ALDH1A3 Antibody Picoband® (ABIN5518802). Tested in Flow Cytometry, IF, IHC, IHC-F, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

    Aufreinigung

    Immunogen affinity purified.

    Immunogen

    E.coli-derived human ALDH1A3 recombinant protein (Position: N37-K154). Human ALDH1A3 shares 89% and 87.3% amino acid (aa) sequence identity with mouse and rat ALDH1A3, respectively.

    Isotyp

    IgG
  • Applikationshinweise

    Western blot, 0.1-0.5 μg/mL, Human, Mouse, Rat
    Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human, Mouse, Rat
    Immunohistochemistry (Frozen Section), 0.5-1 μg/mL, Human
    Immunocytochemistry/Immunofluorescence, 2 μg/mL, Human
    Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human1. Nishimura M, Yoshitsugu H, Naito S, Hiraoka I (2002). "Evaluation of gene induction of drug-metabolizing enzymes and transporters in primary culture of human hepatocytes using high-sensitivity real-time reverse transcription PCR.". Yakugaku Zasshi. 122 (5): 339-61. 2. Rexer BN, Zheng WL, Ong DE (2001). "Retinoic acid biosynthesis by normal human breast epithelium is via aldehyde dehydrogenase 6, absent in MCF-7 cells.". Cancer Res. 61 (19): 7065-70. 3. Yoshida A, Rzhetsky A, Hsu LC, Chang C (1998). "Human aldehyde dehydrogenase gene family.". Eur. J. Biochem. 251 (3): 549-57.

    Kommentare

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Lyophilized

    Rekonstitution

    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

    Konzentration

    500 μg/mL

    Buffer

    Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
  • Target

    ALDH1A3 (Aldehyde Dehydrogenase 1 Family, Member A3 (ALDH1A3))

    Andere Bezeichnung

    ALDH1A3

    Hintergrund

    Synonyms: Aldehyde dehydrogenase family 1 member A3,1.2.1.5,Aldehyde dehydrogenase 6,Retinaldehyde dehydrogenase 3,RALDH-3,RalDH3,ALDH1A3,ALDH6,

    Tissue Specificity: Expressed at low levels in many tissues and at higher levels in salivary gland, stomach, and kidney.

    Background: Aldehyde dehydrogenase 1 family, member A3, also known as ALDH1A3 or retinaldehyde dehydrogenase 3 (RALDH3), is an enzyme that in humans is encoded by the ALDH1A3 gene. Aldehyde dehydrogenase isozymes are thought to play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. The enzyme encoded by this gene uses retinal as a substrate, either in a free or a cellular retinol-binding protein form. Mutations in this gene have been associated with microphthalmia, isolated 8, and expression changes have also been detected in tumor cells. Alternative splicing results in multiple transcript variants.

    Molekulargewicht

    56 kDa

    Gen-ID

    220

    UniProt

    P47895

    Pathways

    Retinoic Acid Receptor Signaling Pathway
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