LMO1 Antikörper (C-Term)

Produktnummer ABIN5518772

Dieses Anti-LMO1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von LMO1 in WB. Geeignet für Human, Ratte und Maus.

Kurzübersicht für LMO1 Antikörper (C-Term) (ABIN5518772)

Target: LMO1 (LIM Domain Only 1 (Rhombotin 1) (LMO1))

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser LMO1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-LMO1 Antikörper

Bindungsspezifität: AA 127-156, C-Term

Verwendungszweck: Anti-LMO1 Antibody Picoband®

Sequenz: DKFFLKNNMI LCQMDYEEGQ LNGTFESQVQ

Kreuzreaktivität (Details): No cross-reactivity with other proteins.

Produktmerkmale: Anti-LMO1 Antibody Picoband® (ABIN5518772). Tested in WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Aufreinigung: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human LMO1, different from the related mouse sequence by two amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot, 0.1-0.5 μg/mL, Human, Mouse, Rat
1. "Entrez Gene: LMO1 LIM domain only 1 (rhombotin 1)". 2. Boehm T, Foroni L, Kaneko Y, Perutz MF, Rabbitts TH (June 1991). "The rhombotin family of cysteine-rich LIM-domain oncogenes: distinct members are involved in T-cell translocations to human chromosomes 11p15 and 11p13". Proc Natl Acad Sci U S A. 88 (10): 4367-71. 3. McGuire EA, Davis AR, Korsmeyer SJ (March 1991). "T-cell translocation gene 1 (Ttg-1) encodes a nuclear protein normally expressed in neural lineage cells". Blood. 77 (3): 599-606.

Kommentare:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na₂HPO₄, 0.05 mg NaN₃.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Details zu LMO1

Target: LMO1 (LIM Domain Only 1 (Rhombotin 1) (LMO1))

Andere Bezeichnung: LMO1

Hintergrund:

Synonyms: Rhombotin-1,Cysteine-rich protein TTG-1,LIM domain only protein 1,LMO-1,T-cell translocation protein 1,LMO1,RBTN1, RHOM1, TTG1,

Tissue Specificity: Expressed mainly in the central nervous. Low level of expression in other tissues including thymus. .

Background: Rhombotin-1 is a protein that in humans is encoded by the LMO1 gene. This locus encodes a transcriptional regulator that contains two cysteine-rich LIM domains but lacks a DNA-binding domain. LIM domains may play a role in protein interactions, thus the encoded protein may regulate transcription by competitively binding to specific DNA-binding transcription factors. Alterations at this locus have been associated with acute lymphoblastic T-cell leukemia. Chromosomal rearrangements have been observed between this locus and at least two loci, the delta subunit of the T-cell antigen receptor gene and the LIM domain binding 1 gene. Alternatively spliced transcript variants have been described.

Molekulargewicht: 18 kDa

Gen-ID: 4004

UniProt: P25800

Pathways: Dopaminergic Neurogenesis