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CYGB Antikörper (AA 1-190)

Der Kaninchen Polyklonal Anti-CYGB-Antikörper wurde für WB und IHC validiert. Er ist geeignet, CYGB in Proben von Human, Ratte und Maus zu detektieren.
Produktnummer ABIN5518753

Kurzübersicht für CYGB Antikörper (AA 1-190) (ABIN5518753)

Target

Alle CYGB Antikörper anzeigen
CYGB (Cytoglobin (CYGB))

Reaktivität

  • 44
  • 18
  • 6
  • 1
Human, Ratte, Maus

Wirt

  • 40
  • 9
Kaninchen

Klonalität

  • 41
  • 8
Polyklonal

Konjugat

  • 33
  • 3
  • 3
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser CYGB Antikörper ist unkonjugiert

Applikation

  • 34
  • 22
  • 16
  • 9
  • 9
  • 9
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
Western Blotting (WB), Immunohistochemistry (IHC)
  • Bindungsspezifität

    • 16
    • 10
    • 6
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 1-190

    Verwendungszweck

    Anti-Cytoglobin/CYGB Antibody Picoband®

    Kreuzreaktivität (Details)

    No cross-reactivity with other proteins

    Produktmerkmale

    Anti-Cytoglobin/CYGB Antibody Picoband® (ABIN5518753). Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

    Aufreinigung

    Immunogen affinity purified.

    Immunogen

    E.coli-derived human Cytoglobin recombinant protein (Position: M1-P190). Human Cytoglobin shares 95.3% and 93.7% amino acid (aa) sequence identity with mouse and rat Cytoglobin, respectively.

    Isotyp

    IgG
  • Applikationshinweise

    Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human, Mouse, Rat
    Western blot, 0.1-0.5 μg/mL, Mouse, Rat, Human
    1. Asahina, K., Kawada, N., Kristensen, D. B., Nakatani, K., Seki, S., Shiokawa, M., Tateno, C., Obara, M., Yoshizato, K. Characterization of human stellate cell activation-associated protein and its expression in human liver. Biochim. Biophys. Acta 1577: 471-475, 2002. 2. Burmester, T., Ebner, B., Weich, B., Hankeln, T. Cytoglobin: a novel globin type ubiquitously expressed in vertebrate tissues. Molec. Biol. Evol. 19: 416-421, 2002. 3. Geuens, E., Brouns, I., Flamez, D., Dewilde, S., Timmermans, J.-P., Moens, L. A globin in the nucleus! J. Biol. Chem. 278: 30417-30420, 2003.

    Kommentare

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Lyophilized

    Rekonstitution

    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

    Konzentration

    500 μg/mL

    Buffer

    Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
  • Target

    CYGB (Cytoglobin (CYGB))

    Andere Bezeichnung

    CYGB

    Hintergrund

    Synonyms: Cytoglobin,Histoglobin,HGb,Stellate cell activation-associated protein,CYGB,STAP,

    Tissue Specificity: Ubiquitously expressed. Highest expression in heart, stomach, bladder and small intestine. .

    Background: Cytoglobin (CYGB), also called HGB or STAP, is a ubiquitously expressed hexacoordinate hemoglobin that may facilitate diffusion of oxygen through tissues, scavenge nitric oxide or other reactive oxygen species, or serve a protective function during oxidative stress. The cytoglobin gene is mapped on 17q25.1. The CYGB gene contains 4 exons and spans about 9 kb. Cytoglobin has many elements common to vertebrate globins, including invariant histidine residues, and the amino acids that form the heme pocket share similarity with pentacoordinate myoglobin. In contrast to the high oxygen affinities displayed by most hexacoordinate hemoglobins, the characteristics of CYGB indicate that it can facilitate oxygen transport. Because the oxygen affinity of CYGB is more similar to myoglobin than to neuroglobin, and the oxy form of CYGB resists autooxidation, CYGB is proposed to represent a tissue oxygen reservoir.

    Molekulargewicht

    21 kDa

    Gen-ID

    114757
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