APEX2 Antikörper (AA 102-210)

Produktnummer ABIN5518737

Produktdetails anti-APEX2 Antikörper

Target: APEX2 (APEX Nuclease (Apurinic/apyrimidinic Endonuclease) 2 (APEX2))

Bindungsspezifität: AA 102-210

Reaktivität: Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser APEX2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Verwendungszweck: Rabbit IgG polyclonal antibody for DNA-(apurinic or apyrimidinic site) lyase 2(APEX2) detection. Tested with WB in Human,Rat.

Kreuzreaktivität (Details): Predicted Cross Reactivity: human
No cross reactivity with other proteins.
Predicted Cross Reactivity: Species predicted to be fit for the product based on sequence similarities.

Produktmerkmale: Rabbit IgG polyclonal antibody for DNA-(apurinic or apyrimidinic site) lyase 2(APEX2) detection. Tested with WB in Human,Rat.
Gene Name: APEX nuclease (apurinic/apyrimidinic endonuclease) 2
Protein Name: DNA-(apurinic or apyrimidinic site) lyase 2

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human APEX2 recombinant protein (Position: L102-A210). Human APEX2 shares 91.7% amino acid (aa) sequence identity with mouse APEX2.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Rat, Predicted Species: Human
Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities.
Other applications have not been tested. Optimal dilutions should be determined by end users.

Kommentare:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Details zu APEX2

Target: APEX2 (APEX Nuclease (Apurinic/apyrimidinic Endonuclease) 2 (APEX2))

Andere Bezeichnung: APEX2 (APEX2 Produkte)

Synonyme: APE2 antikoerper, APEXL2 antikoerper, XTH2 antikoerper, ape2 antikoerper, apexl2 antikoerper, xth2 antikoerper, zgc:55889 antikoerper, C430040P13Rik antikoerper, apurinic/apyrimidinic endodeoxyribonuclease 2 antikoerper, APEX nuclease (apurinic/apyrimidinic endonuclease) 2 antikoerper, apurinic/apyrimidinic endodeoxyribonuclease 2 L homeolog antikoerper, apurinic/apyrimidinic endonuclease 2 antikoerper, APEX2 antikoerper, apex2 antikoerper, apex2.L antikoerper, Apex2 antikoerper

Hintergrund: APEX2, also called apurinic/apyrimidinic endonuclease like-2, is a member of the apurinic/apyrimidinic (AP) family of endonucleases that initiate the repair of AP sites formed by spontaneous hydrolysis of the N-glycosylic bond, mutagen-induced base release, or damaged-base excision by a DNA repair glycosylase. RT-PCR detected APEX2 expression in HeLa cells, Jurkat cells, and human kidney, brain and fetal brain tissue. The APEX2 gene is mapped to chromosome Xp11.21. APEX2 participates in both nuclear and mitochondrial base excision repair (BER) and it can play a role in processing 3-prime-damaged termini or 3-prime-mismatched nucleotides. Additionally, APEX2 displayed weaker AP site-specific and 3-prime nuclease activities compared to APEX1.

Synonyms: AP endonuclease XTH2 | APE2 | APE2 | XTH2 | APEX nuclease-like 2 | APEX2 | APEXL 2 | APEXL2 | Q9UBZ4 | XTH 2

Gen-ID: 27301