THOC7 Antikörper (C-Term)

Produktnummer ABIN5517619

Produktdetails anti-THOC7 Antikörper

Target: THOC7 (THO Complex 7 (THOC7))

Bindungsspezifität: C-Term

Reaktivität: Human, Ratte, Rind (Kuh), Hund, Meerschweinchen, Pferd, Kaninchen, Schwein

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser THOC7 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: SVEDKLELRR KQFHVLLSTI HELQQTLEND EKLSEVEEAQ EASMETDPKP

Homologie: Cow: 100%, Dog: 93%, Guinea Pig: 79%, Horse: 86%, Human: 100%, Pig: 93%, Rabbit: 79%, Rat: 79%

Produktmerkmale: This is a rabbit polyclonal antibody against THOC7. It was validated on Western Blot.

Aufreinigung: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human THOC7

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu THOC7

Target: THOC7 (THO Complex 7 (THOC7))

Andere Bezeichnung: THOC7 (THOC7 Produkte)

Hintergrund: THOC7 is required for efficient export of polyadenylated RNA. It acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production.

Alias Symbols: THOC7, NIF3L1BP1,

Protein Interaction Partner: THOC2, RPA3, RPA2, RPA1, CKAP4, UBC, ZC3H15, TRMT112, PPIP5K2, THOC1, UBE3C, USP13, ZPR1, THOC5, VIM, S100A13, WDR36, ZCRB1, THOC3, ZNF606, THOC6, ALYREF, DDX39B, NIF3L1, CHD3, MED8, GOT2, MED18, MED22,

Protein Size: 204

Gen-ID: 80145

NCBI Accession: NP_079351

UniProt: Q6I9Y2