RAS Guanyl Releasing Protein 1 (Calcium and DAG-Regulated) (RASGRP1) (Middle Region) Antikörper

Details zu Produkt Nr. ABIN5517466
Antigen
  • Rasgrp
  • CALDAG-GEFI
  • CALDAG-GEFII
  • RASGRP
  • V
  • hRasGRP1
  • RAS guanyl releasing protein 1
  • Rasgrp1
  • RASGRP1
Epitop
Middle Region
10
8
7
7
4
1
1
Reaktivität
Human
29
2
2
2
1
1
1
1
Wirt
Kaninchen
29
Klonalität
Polyklonal
Konjugat
Unkonjugiert
3
3
3
2
2
2
Applikation
Western Blotting (WB)
25
18
17
17
2
1
Optionen
Immunogen The immunogen is a synthetic peptide directed towards the middle region of human RASGRP1
Sequenz GLCHSSISRL KETSSHVPHE INKVLGEMTE LLSSSRNYDN YRRAYGECTD
Reinigung Affinity purified
Antigen
Andere Bezeichnung RASGRP1 (RASGRP1 Antibody Abstract)
Hintergrund This gene is a member of a family of genes characterized by the presence of a Ras superfamily guanine nucleotide exchange factor (GEF) domain. It functions as a diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. It activates the Erk/MAP kinase cascade and regulates T-cells and B-cells development, homeostasis and differentiation. Alternatively spliced transcript variants encoding different isoforms have been identified. Altered expression of the different isoforms of this protein may be a cause of susceptibility to systemic lupus erythematosus (SLE).

Alias Symbols: V, RASGRP, hRasGRP1, CALDAG-GEFI, CALDAG-GEFII

Protein Size: 797
Gen-ID 10125
NCBI Accession NM_001128602, NP_001122074
UniProt O95267
Pathways T-Zell Rezeptor Signalweg, Fc-epsilon Rezeptor Signalübertragung
Applikations-hinweise Optimal working dilution should be determined by the investigator.
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Buffer Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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