MC1 Receptor Antikörper (N-Term)

Produktnummer ABIN5517430

Der Kaninchen Polyklonal Anti-MC1 Receptor Antikörper wurde für WB validiert. Er ist geeignet, MC1 Receptor in Proben von Human zu detektieren.

Kurzübersicht für MC1 Receptor Antikörper (N-Term) (ABIN5517430)

Target: MC1 Receptor (MC1R) (Melanocortin 1 Receptor (MC1R))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MC1 Receptor Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-MC1 Receptor Antikörper

Bindungsspezifität: N-Term

Sequenz: QRRLLGSLNS TPTAIPQLGL AANQTGARCL EVSISDGLFL SLGLVSLVEN

Aufreinigung: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human MC1R

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu MC1 Receptor

Target: MC1 Receptor (MC1R) (Melanocortin 1 Receptor (MC1R))

Andere Bezeichnung: MC1R

Hintergrund: This intronless gene encodes the receptor protein for melanocyte-stimulating hormone (MSH). The encoded protein, a seven pass transmembrane G protein coupled receptor, controls melanogenesis. Two types of melanin exist: red pheomelanin and black eumelanin. Gene mutations that lead to a loss in function are associated with increased pheomelanin production, which leads to lighter skin and hair color. Eumelanin is photoprotective but pheomelanin may contribute to UV-induced skin damage by generating free radicals upon UV radiation. Binding of MSH to its receptor activates the receptor and stimulates eumelanin synthesis. This receptor is a major determining factor in sun sensitivity and is a genetic risk factor for melanoma and non-melanoma skin cancer. Over 30 variant alleles have been identified which correlate with skin and hair color, providing evidence that this gene is an important component in determining normal human pigment variation.

Alias Symbols: CMM5, MSH-R, SHEP2

Protein Size: 317

Gen-ID: 4157

NCBI Accession: NM_002386, NP_002377

UniProt: Q01726

Pathways: cAMP Metabolic Process, Feeding Behaviour