PDP Antikörper (N-Term)

Produktnummer ABIN5517423

Dieser Kaninchen Polyklonal Antikörper erkennt spezifisch PDP in WB. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für PDP Antikörper (N-Term) (ABIN5517423)

Target: PDP (Pyruvate Dehydrogenase Phosphatase (PDP))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PDP Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-PDP Antikörper

Bindungsspezifität: N-Term

Sequenz: SSSYIPQSRL RYTPHPAYAT FCRPKENWWQ YTQGRRYAST PQKFYLTPPQ

Aufreinigung: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human PDP1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu PDP

Target: PDP (Pyruvate Dehydrogenase Phosphatase (PDP))

Andere Bezeichnung: PDP1

Hintergrund: Pyruvate dehydrogenase (E1) is one of the three components (E1, E2, and E3) of the large pyruvate dehydrogenase complex. Pyruvate dehydrogenase kinases catalyze phosphorylation of serine residues of E1 to inactivate the E1 component and inhibit the complex. Pyruvate dehydrogenase phosphatases catalyze the dephosphorylation and activation of the E1 component to reverse the effects of pyruvate dehydrogenase kinases. Pyruvate dehydrogenase phosphatase is a heterodimer consisting of catalytic and regulatory subunits. Two catalytic subunits have been reported, one is predominantly expressed in skeletal muscle and another one is is much more abundant in the liver. The catalytic subunit, encoded by this gene, is the former, and belongs to the protein phosphatase 2C (PP2C) superfamily. Along with the pyruvate dehydrogenase complex and pyruvate dehydrogenase kinases, this enzyme is located in the mitochondrial matrix. Mutation in this gene causes pyruvate dehydrogenase phosphatase deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.

Alias Symbols: PDH, PDP, PDPC, PPM2C

Protein Size: 537

Gen-ID: 54704

NCBI Accession: NM_001161779, NP_001155251

UniProt: Q9P0J1