KRIT1 Antikörper (C-Term)

Produktnummer ABIN5516696

Der Kaninchen Polyklonal anti-KRIT1 Antikörper (ABIN5516696) detektiert spezifisch KRIT1 in WB. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für KRIT1 Antikörper (C-Term) (ABIN5516696)

Target: KRIT1 (KRIT1, Ankyrin Repeat Containing (KRIT1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser KRIT1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-KRIT1 Antikörper

Bindungsspezifität: C-Term

Sequenz: LLQIVYGNYE SKKHKQGFLN EENLKSIVPV TKLKSKAPHW TNRILHEYKN

Aufreinigung: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human KRIT1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu KRIT1

Target: KRIT1 (KRIT1, Ankyrin Repeat Containing (KRIT1))

Andere Bezeichnung: KRIT1

Hintergrund: This gene encodes a protein containing four ankyrin repeats, a band 4.1/ezrin/radixin/moesin (FERM) domain, and multiple NPXY sequences. The encoded protein is localized in the nucleus and cytoplasm. It binds to integrin cytoplasmic domain-associated protein-1 alpha (ICAP1alpha), and plays a critical role in beta1-integrin-mediated cell proliferation. It associates with junction proteins and RAS-related protein 1A (Rap1A), which requires the encoded protein for maintaining the integrity of endothelial junctions. It is also a microtubule-associated protein and may play a role in microtubule targeting. Mutations in this gene result in cerebral cavernous malformations. Multiple alternatively spliced transcript variants have been found for this gene.

Alias Symbols: CAM, CCM1

Protein Size: 529

Gen-ID: 889

NCBI Accession: NM_001013406

Pathways: Cell RedoxHomeostasis