KRIT1 Antikörper (C-Term)

Produktnummer ABIN5516696

Der Kaninchen Polyklonal anti-KRIT1 Antikörper (ABIN5516696) detektiert spezifisch KRIT1 in WB. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für KRIT1 Antikörper (C-Term) (ABIN5516696)

Target: KRIT1 (KRIT1, Ankyrin Repeat Containing (KRIT1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser KRIT1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-KRIT1 Antikörper

Bindungsspezifität: C-Term

Verwendungszweck: KRIT1 Antibody - C-terminal region

Sequenz: LLQIVYGNYE SKKHKQGFLN EENLKSIVPV TKLKSKAPHW TNRILHEYKN

Aufreinigung: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human KRIT1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP74923-100UG

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Details zu KRIT1

Target: KRIT1 (KRIT1, Ankyrin Repeat Containing (KRIT1))

Andere Bezeichnung: KRIT1

Hintergrund:

Background Information: This gene encodes a protein containing four ankyrin repeats, a band 4.1/ezrin/radixin/moesin (FERM) domain, and multiple NPXY sequences. The encoded protein is localized in the nucleus and cytoplasm. It binds to integrin cytoplasmic domain-associated protein-1 alpha (ICAP1alpha), and plays a critical role in beta1-integrin-mediated cell proliferation. It associates with junction proteins and RAS-related protein 1A (Rap1A), which requires the encoded protein for maintaining the integrity of endothelial junctions. It is also a microtubule-associated protein and may play a role in microtubule targeting. Mutations in this gene result in cerebral cavernous malformations. Multiple alternatively spliced transcript variants have been found for this gene.

Gene Name: KRIT1, ankyrin repeat containing

Alternative Symbols: CAM, CCM1

Protein Name: krev interaction trapped protein 1

Molekulargewicht: 58 kDa

Gen-ID: 889

UniProt: O00522

Pathways: Cell RedoxHomeostasis