Urm1 Antikörper (N-Term)

Produktnummer ABIN5516189

Der Kaninchen Polyklonal anti-Urm1 Antikörper (ABIN5516189) detektiert spezifisch Urm1 in WB. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für Urm1 Antikörper (N-Term) (ABIN5516189)

Target: Urm1 (Ubiquitin Related Modifier 1 (Urm1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Urm1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-Urm1 Antikörper

Bindungsspezifität: N-Term

Sequenz: TLPGQEEPWD IRNLLIWIKK NLLKERPELF IQGDSVRPGI LVLINDADWE

Produktmerkmale: This is a rabbit polyclonal antibody against URM1. It was validated on Western Blot.

Aufreinigung: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of Human URM1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu Urm1

Target: Urm1 (Ubiquitin Related Modifier 1 (Urm1))

Andere Bezeichnung: URM1

Hintergrund: URM1 acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). URM1 serves as sulfur donor in tRNA 2- thiolation reaction by being thiocarboxylated (-COSH) at its C- terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as MOCS3, ATPBD3, CTU2, USP15 and CAS. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.

Alias Symbols: C9orf74

Protein Interaction Partner: SEC23IP, DSTN, PTGES3, TXNL1, USP5, XPO1, VCL, PRDX2, PRDX1, ATP6V1A, CTU1, UBC, ASCC2, TBL3, CDK11B, UBA4,

Protein Size: 101

Gen-ID: 81605

NCBI Accession: NP_112176

UniProt: Q9BTM9