DAXX Antikörper (N-Term)

Produktnummer ABIN5515954

Der Kaninchen Polyklonal Anti-DAXX-Antikörper wurde für WB validiert. Er ist geeignet, DAXX in Proben von Human zu detektieren.

Kurzübersicht für DAXX Antikörper (N-Term) (ABIN5515954)

Target: DAXX (Death-Domain Associated Protein (DAXX))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DAXX Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-DAXX Antikörper

Bindungsspezifität: N-Term

Sequenz: KLNLAPAATT SNEPSGNNPP THLSLDPTNA ENTASQSPRT RGSRRQIQRL

Produktmerkmale: This is a rabbit polyclonal antibody against DAXX. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of Human DAXX

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu DAXX

Target: DAXX (Death-Domain Associated Protein (DAXX))

Andere Bezeichnung: DAXX

Hintergrund: This gene encodes a multifunctional protein that resides in multiple locations in the nucleus and in the cytoplasm. It interacts with a wide variety of proteins, such as apoptosis antigen Fas, centromere protein C, and transcription factor erythroblastosis virus E26 oncogene homolog 1. In the nucleus, the encoded protein functions as a potent transcription repressor that binds to sumoylated transcription factors. Its repression can be relieved by the sequestration of this protein into promyelocytic leukemia nuclear bodies or nucleoli. This protein also associates with centromeres in G2 phase. In the cytoplasm, the encoded protein may function to regulate apoptosis. The subcellular localization and function of this protein are modulated by post-translational modifications, including sumoylation, phosphorylation and polyubiquitination. Alternative splicing results in multiple transcript variants.

Alias Symbols: Name=DAXX

Protein Interaction Partner: FAM9B, SSX2IP, SUMO1, UBE2I, UBC, GOLGA2, CARD9, PBXIP1, CDCA7L, NECAB2, RASSF1, PML, MDM2, H3F3A, DNMT1, TP53, ATRX, CARM1, PRMT1, WHSC1L1, CUL3, SPOP, HIPK2, PDCD4, DNMT3A, USP7, UBB, RELB, DAXX, CREB1, CBS, ATM, HIST1H4F, HIST1H3C, TRAF3, HIST4H4, BTBD

Protein Size: 740

Gen-ID: 1616

NCBI Accession: NP_001341

UniProt: Q9UER7

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway