APEX2 Antikörper (C-Term)

Produktnummer ABIN5515372

Der Kaninchen Polyklonal anti-APEX2 Antikörper wird verwendet zum Nachweis von APEX2 in Proben von Human. Er wurde validiert für WB.

Kurzübersicht für APEX2 Antikörper (C-Term) (ABIN5515372)

Target: APEX2 (APEX Nuclease (Apurinic/apyrimidinic Endonuclease) 2 (APEX2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser APEX2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-APEX2 Antikörper

Bindungsspezifität: C-Term

Sequenz: LMTPKTPEEK AVAKVVKGQA KTSEAKDEKE LRTSFWKSVL AGPLRTPLCG

Homologie: Cow: 85%, Horse: 93%, Human: 100%, Rat: 77%

Aufreinigung: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human APEX2

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu APEX2

Target: APEX2 (APEX Nuclease (Apurinic/apyrimidinic Endonuclease) 2 (APEX2))

Andere Bezeichnung: APEX2

Hintergrund: Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes a protein shown to have a weak class II AP endonuclease activity. Most of the encoded protein is located in the nucleus but some is also present in mitochondria. This protein may play an important role in both nuclear and mitochondrial base excision repair. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Alias Symbols: APE2, XTH2, ZGRF2, APEXL2

Protein Interaction Partner: UBC, PDE12, APP, NEDD4L, CCDC85B, NINL, HOOK2, PGR, CALCOCO2, TRIM37, EFEMP2, TRAF2, PCNA,

Protein Size: 518

Gen-ID: 27301

NCBI Accession: NM_014481, NP_055296

UniProt: Q9UBZ4