ITM2B Antikörper (N-Term)

Produktnummer ABIN5514896

Der Kaninchen Polyklonal anti-ITM2B Antikörper (ABIN5514896) detektiert spezifisch ITM2B in WB. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für ITM2B Antikörper (N-Term) (ABIN5514896)

Target: ITM2B (Integral Membrane Protein 2B (ITM2B))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ITM2B Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-ITM2B Antikörper

Bindungsspezifität: N-Term

Verwendungszweck: ITM2B Antibody - N-terminal region

Sequenz: FNSALAQKEA KKDEPKSGEE ALIIPPDAVA VDCKDPDDVV PVGQRRAWCW

Aufreinigung: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human ITM2B

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP78186-100UG

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Details zu ITM2B

Target: ITM2B (Integral Membrane Protein 2B (ITM2B))

Andere Bezeichnung: ITM2B

Hintergrund:

Background Information: Amyloid precursor proteins are processed by beta-secretase and gamma-secretase to produce beta-amyloid peptides which form the characteristic plaques of Alzheimer disease. This gene encodes a transmembrane protein which is processed at the C-terminus by furin or furin-like proteases to produce a small secreted peptide which inhibits the deposition of beta-amyloid. Mutations which result in extension of the C-terminal end of the encoded protein, thereby increasing the size of the secreted peptide, are associated with two neurogenerative diseases, familial British dementia and familial Danish dementia.

Gene Name: integral membrane protein 2B

Alternative Symbols: BRI, FBD, ABRI, BRI2, E25B, E3-16, RDGCA, imBRI2, BRICD2B

Protein Name: integral membrane protein 2B

Molekulargewicht: 29 kDa

Gen-ID: 9445

NCBI Accession: NP_068839

UniProt: Q9Y287