PNP Antikörper (Middle Region)

Produktnummer ABIN5514791

Der Kaninchen Polyklonal anti-PNP Antikörper (ABIN5514791) detektiert spezifisch PNP in WB. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für PNP Antikörper (Middle Region) (ABIN5514791)

Target: PNP (Purine Nucleoside Phosphorylase (PNP))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PNP Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-PNP Antikörper

Bindungsspezifität: Middle Region

Verwendungszweck: PNP Antibody - middle region

Sequenz: IMLIRDHINL PGFSGQNPLR GPNDERFGDR FPAMSDAYDR TMRQRALSTW

Produktmerkmale: This is a rabbit polyclonal antibody against PNPH. It was validated on Western Blot.

Aufreinigung: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of Human PNPH

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP75005-100UG

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Details zu PNP

Target: PNP (Purine Nucleoside Phosphorylase (PNP))

Andere Bezeichnung: PNP

Hintergrund:

Background Information: This gene encodes an enzyme which reversibly catalyzes the phosphorolysis of purine nucleosides. The enzyme is trimeric, containing three identical subunits. Mutations which result in nucleoside phosphorylase deficiency result in defective T-cell (cell-mediated) immunity but can also affect B-cell immunity and antibody responses. Neurologic disorders may also be apparent in patients with immune defects. A known polymorphism at aa position 51 that does not affect enzyme activity has been described. A pseudogene has been identified on chromosome 2.

Gene Name: purine nucleoside phosphorylase

Alternative Symbols: NP, PUNP, PRO1837

Protein Name: purine nucleoside phosphorylase

Molekulargewicht: 31kDa

Gen-ID: 4860

NCBI Accession: NP_000261

UniProt: P00491

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Ribonucleoside Biosynthetic Process, Positive Regulation of Response to DNA Damage Stimulus