CKMT1A Antikörper (C-Term)

Produktnummer ABIN5514690

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch CKMT1A in WB. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für CKMT1A Antikörper (C-Term) (ABIN5514690)

Target: CKMT1A (Creatine Kinase, Mitochondrial 1A (CKMT1A))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CKMT1A Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-CKMT1A Antikörper

Bindungsspezifität: C-Term

Sequenz: QKRGTGGVDT AATGGVFDIS NLDRLGKSEV ELVQLVIDGV NYLIDCERRL

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 93%

Aufreinigung: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human CKMT1A

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu CKMT1A

Target: CKMT1A (Creatine Kinase, Mitochondrial 1A (CKMT1A))

Andere Bezeichnung: CKMT1A

Hintergrund: Mitochondrial creatine (MtCK) kinase is responsible for the transfer of high energy phosphate from mitochondria to the cytosolic carrier, creatine. It belongs to the creatine kinase isoenzyme family. It exists as two isoenzymes, sarcomeric MtCK and ubiquitous MtCK, encoded by separate genes. Mitochondrial creatine kinase occurs in two different oligomeric forms: dimers and octamers, in contrast to the exclusively dimeric cytosolic creatine kinase isoenzymes. Many malignant cancers with poor prognosis have shown overexpression of ubiquitous mitochondrial creatine kinase, this may be related to high energy turnover and failure to eliminate cancer cells via apoptosis. Ubiquitous mitochondrial creatine kinase has 80 % homology with the coding exons of sarcomeric mitochondrial creatine kinase. Two genes located near each other on chromosome 15 have been identified which encode identical mitochondrial creatine kinase proteins.

Alias Symbols: CKMT1, U-MtCK, mia-CK

Protein Interaction Partner: UBC, MDM2, SUZ12, gag-pol, CUL3, ASB9, VDAC1, SLC25A5, CKMT1A,

Protein Size: 417

Gen-ID: 548596

NCBI Accession: NM_001015001, NP_001015001

UniProt: P12532