B3GAT3 Antikörper (AA 1-335)

Produktnummer ABIN525639

Zitiert in 4+ Publikationen. Der Maus Polyklonal anti-B3GAT3 Antikörper (ABIN525639) detektiert spezifisch B3GAT3 in WB. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für B3GAT3 Antikörper (AA 1-335) (ABIN525639)

Target: B3GAT3 (beta-1,3-Glucuronyltransferase 3 (Glucuronosyltransferase I) (B3GAT3))

Reaktivität: Human

Wirt: Maus

Klonalität: Polyklonal

Konjugat: Dieser B3GAT3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-B3GAT3 Antikörper

Bindungsspezifität: AA 1-335

Verwendungszweck: Mouse polyclonal antibody raised against a full-length human B3GAT3 protein.

Sequenz: MKLKLKNVFL AYFLVSIAGL LYALVQLGQP CDCLPPLRAA AEQLRQKDLR ISQLQAELRR PPPAPAQPPE PEALPTIYVV TPTYARLVQK AELVRLSQTL SLVPRLHWLL VEDAEGPTPL VSGLLAASGL LFTHLVVLTP KAQRLREGEP GWVHPRGVEQ RNKALDWLRG RGGAVGGEKD PPPPGTQGVV YFADDDNTYS RELFEEMRWT RGVSVWPVGL VGGLRFEGPQ VQDGRVVGFH TAWEPSRPFP VDMAGFAVAL PLLLDKPNAQ FDSTAPRGHL ESSLLSHLVD PKDLEPRAAN CTRVLVWHTR TEKPKMKQEE QLQRQGRGSD PAIEV

Kreuzreaktivität: Human

Produktmerkmale: Antibody reactive against mammalian transfected lysate.

Immunogen: B3GAT3 (NP_036332.2, 1 a.a. ~ 335 a.a) full-length human protein.

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: In 1x PBS, pH 7.4

Handhabung: Aliquot to avoid repeated freezing and thawing.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.

Referenzen für anti-B3GAT3 Antikörper (ABIN525639)

Job, Mizumoto, Smith, Couser, Brazil, Saal, Patterson, Gibson, Soden, Miller, Thiffault, Saunders, Yamada, Hoffmann, Sugahara, Farrow: "Functional validation of novel compound heterozygous variants in B3GAT3 resulting in severe osteopenia and fractures: expanding the disease phenotype." in: BMC medical genetics, Vol. 17, Issue 1, pp. 86, (2016) (PubMed).

Budde, Mizumoto, Kogawa, Becker, Altmüller, Thiele, Rüschendorf, Toliat, Kaleschke, Hämmerle, Höhne, Sugahara, Nürnberg, Kennerknecht: "Skeletal dysplasia in a consanguineous clan from the island of Nias/Indonesia is caused by a novel mutation in B3GAT3." in: Human genetics, Vol. 134, Issue 7, pp. 691-704, (2015) (PubMed).

Baasanjav, Al-Gazali, Hashiguchi, Mizumoto, Fischer, Horn, Seelow, Ali, Aziz, Langer, Saleh, Becker, Nürnberg, Cantagrel, Gleeson, Gomez, Michel, Stricker, Lindner, Nürnberg, Sugahara, Mundlos et al.: "Faulty initiation of proteoglycan synthesis causes cardiac and joint defects. ..." in: American journal of human genetics, Vol. 89, Issue 1, pp. 15-27, (2011) (PubMed).

Hiyama, Gajghate, Sakai, Mochida, Shapiro, Risbud: "Activation of TonEBP by calcium controls {beta}1,3-glucuronosyltransferase-I expression, a key regulator of glycosaminoglycan synthesis in cells of the intervertebral disc." in: The Journal of biological chemistry, Vol. 284, Issue 15, pp. 9824-34, (2009) (PubMed).

Details zu B3GAT3

Target: B3GAT3 (beta-1,3-Glucuronyltransferase 3 (Glucuronosyltransferase I) (B3GAT3))

Andere Bezeichnung: B3GAT3

Hintergrund: Full Gene Name: beta-1,3-glucuronyltransferase 3 (glucuronosyltransferase I)
Synonyms: GLCATI,GlcAT-I

Gen-ID: 26229

NCBI Accession: NM_012200

Pathways: Glycosaminoglycan Metabolic Process