VAV2 Antikörper (AA 610-824)

Produktnummer ABIN5027629

Der Kaninchen Polyklonal Anti-VAV2-Antikörper wurde für WB validiert. Er ist geeignet, VAV2 in Proben von Human zu detektieren.

Kurzübersicht für VAV2 Antikörper (AA 610-824) (ABIN5027629)

Target: VAV2 (Vav 2 Guanine Nucleotide Exchange Factor (VAV2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser VAV2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-VAV2 Antikörper

Bindungsspezifität: AA 610-824

Aufreinigung: Protein A Chromatography

Immunogen: A partial length recombinant VAV2 protein (amino acids 610-824) was used as the immunogen for this antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1-2 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: PBS containing 0.05 % BSA, PH 7.4

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Details zu VAV2

Target: VAV2 (Vav 2 Guanine Nucleotide Exchange Factor (VAV2))

Andere Bezeichnung: VAV2

Hintergrund: Vav2 is a member of the Vav family that serves as a GRF (guanine nucleotide exchange factor) for the Rho family of Ras-related GTPases. It is widely expressed and regulates processes including cell migration, neuronal development and phagocytosis through interactions with different proteins. Vav2, a GEF for Rac1, RhoA, and Cdc42, is shown to be regulated by a phosphorylation-dependent interaction with PKL (Paxillin kinase linker). PKL is required for Vav2 activation downstream of integrin engagement and epidermal growth factor (EGF) stimulation. During the process of spinal neurons, the Vav2 activity is necessary for optimal neurite outgrowth and promotes branching by targeting GEF activity to branch points.

Molekulargewicht: 90 kDa

Gen-ID: 7410

UniProt: P52735

Pathways: Fc-epsilon Rezeptor Signalübertragung, Neurotrophin Signalübertragung