TIA1 Antikörper (AA 182-385)

Produktnummer ABIN5027559

Dieser Maus Monoklonal Antikörper detektiert spezifisch TIA1 in WB und IHC. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für TIA1 Antikörper (AA 182-385) (ABIN5027559)

Target: TIA1 (TIA1 Cytotoxic Granule-Associated RNA Binding Protein (TIA1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser TIA1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Klon: ABM47E1

Produktdetails anti-TIA1 Antikörper

Bindungsspezifität: AA 182-385

Aufreinigung: Protein G Chromatography

Immunogen: A partial length recombinant TIA-1 protein (amino acids 182-385) was used as the immunogen for this antibody.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: WB: 2-4 μg/mL, IHC: 5-10 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: PBS containing 0.05 % BSA, PH 7.4

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Details zu TIA1

Target: TIA1 (TIA1 Cytotoxic Granule-Associated RNA Binding Protein (TIA1))

Andere Bezeichnung: TIA-1

Hintergrund: TIA1 (T-cell intracellular antigen) are mRNA-binding proteins that can aggregate within granules under specific stress conditions. TIA-1 is a multi-domain ribonucleic acid (RNA) binding protein that recognizes poly-uridine tract RNA sequences to facilitate 5'splice site recognition by the U1 small nuclear ribonucleoprotein (snRNP). TIA1 mutation causes perturbed RNA splicing and cellular stress resulting in WDM (Welander distal myopathy). TIA-1 regulates developmental and stress-responsive pathways through distinct activities at the levels of alternative pre-mRNA splicing and mRNA translation by recognising uridine-rich sequences of RNAs.

Molekulargewicht: 44 kDa

Gen-ID: 7072

UniProt: P31483