MUL1 Antikörper (AA 146-352)

Produktnummer ABIN5027374

Produktdetails anti-MUL1 Antikörper

Target: MUL1 (Mitochondrial E3 Ubiquitin Protein Ligase 1 (MUL1))

Bindungsspezifität: AA 146-352

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser MUL1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Aufreinigung: Protein G Chromatography

Immunogen: A partial length recombinant MUL1 protein (amino acids 146-352) was used as the immunogen for this antibody.

Klon: ABM4F71

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: WB: 4-8 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: PBS containing 0.05 % BSA, PH 7.4

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Details zu MUL1

Target: MUL1 (Mitochondrial E3 Ubiquitin Protein Ligase 1 (MUL1))

Andere Bezeichnung: MUL1 (MUL1 Produkte)

Hintergrund: MUL1 (Mitochondrial E3 Ubiquitin Protein Ligase-1) is a crucial moderator of RIG-I (Retinoic Acid-Inducible-Gene-I) signaling. This protein is localized to the mitochondria where it interacts with MAVS (Mitochondrial Antiviral Signaling) and catalyzes RIG-I post-translational modifications that inhibit RIG-I-dependent cell signaling. MUL1 contains a unique BAM (Beside A Membrane) domain and a C-terminal RING-finger domain. This protein has been implicated in several processes that occur in animal cells such as NF-KappaB activation, innate immunity and antiviral signaling, suppression of PINK1/parkin defects, mitophagy in skeletal muscle, and caspase-dependent apoptosis.

Molekulargewicht: 40 kDa

Gen-ID: 79594

UniProt: Q969V5

Pathways: Positive Regulation of Endopeptidase Activity