Importin 8 Antikörper (AA 700-1000)

Produktnummer ABIN5027312

Dieses Anti-Importin 8-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von Importin 8 in WB. Geeignet für Human.

Kurzübersicht für Importin 8 Antikörper (AA 700-1000) (ABIN5027312)

Target: Importin 8 (IPO8)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Importin 8 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-Importin 8 Antikörper

Bindungsspezifität: AA 700-1000

Aufreinigung: Protein A Chromatography

Immunogen: A partial length recombinant Importin-8 protein (amino acids 700-1,000) was used as the immunogen for this antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 2-4 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: PBS containing 0.05 % BSA, PH 7.4

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Details zu Importin 8

Target: Importin 8 (IPO8)

Andere Bezeichnung: Importin-8

Hintergrund: Importin-8 is a member of a class of approximately 20 potential Ran targets that share a sequence motif related to the Ran-binding site of importin-beta. It acts as a nuclear protein involved in the nucleolar transport. Importin-8 is required for cytoplasmic miRNA-guided gene silencing and is involved in loading Ago complexes into a variety of different mRNA targets, affecting the nuclear localization of Ago proteins. This protein binds to the nuclear pore complex and, along with RanGTP and RANBP1, inhibits the GAP stimulation of the Ran GTPase. The importin-alpha/beta complex and the GTPase Ran mediate nuclear import of proteins with a classical nuclear localization signal. Importin-8 has been proposed previously as a reference gene in the human motor cortex as it showed no differences in a study with different brain regions from chronic alcoholics and control subjects and lung samples.

Molekulargewicht: 118 kDa

Gen-ID: 10526

UniProt: O15397