OTUD5 Antikörper (AA 300-520)
Kurzübersicht für OTUD5 Antikörper (AA 300-520) (ABIN5027170)
Target
Alle OTUD5 Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
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Bindungsspezifität
- AA 300-520
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Kreuzreaktivität
- Maus
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Aufreinigung
- Protein A Chromatography
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Immunogen
- A partial length recombinant DUBA protein (amino acids 300-520) was used as the immunogen for this antibody.
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Isotyp
- IgG
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Applikationshinweise
- WB: 2-4 μg/mL
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Konzentration
- 0.5 mg/mL
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Buffer
- PBS containing 0.05 % BSA, PH 7.4
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Konservierungsmittel
- Sodium azide
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Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Lagerung
- 4 °C/-20 °C
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Informationen zur Lagerung
- Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
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- OTUD5 (OTU Domain Containing 5 (OTUD5))
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Andere Bezeichnung
- DUBA
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Hintergrund
- DUBA belongs to a subfamily of 14 DUBs characterized by an OTU (Ovarian Tumor) domain. This protein suppress the type I interferon-dependent innate immune response by cleaving the polyubiquitin chain from an essential type I interferon adaptor protein. Cleavage results in disassociation of the adaptor protein from a downstream signaling complex and disruption of the type I interferon signaling cascade. DUBA forms a direct complex with p53 and controls level of ubiquitination. The function of DUBA is required to allow the rapid activation of p53-dependent transcription and a p53-dependent apoptosis in response to DNA damage stress.
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Molekulargewicht
- 62 kDa
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Gen-ID
- 55593
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UniProt
- Q96G74
Target
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