beta Arrestin 1 Antikörper (AA 150-318)

Produktnummer ABIN5027057

Dieses Anti-beta Arrestin 1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von beta Arrestin 1 in WB. Geeignet für Human.

Kurzübersicht für beta Arrestin 1 Antikörper (AA 150-318) (ABIN5027057)

Target: beta Arrestin 1 (ARRB1) (Arrestin, beta 1 (ARRB1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser beta Arrestin 1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-beta Arrestin 1 Antikörper

Bindungsspezifität: AA 150-318

Aufreinigung: Protein A Chromatography

Immunogen: A partial length recombinant Beta-arrestin 1 protein (amino acids 150-318) was used as the immunogen for this antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 2-4 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: PBS containing 0.05 % BSA, PH 7.4

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Details zu beta Arrestin 1

Target: beta Arrestin 1 (ARRB1) (Arrestin, beta 1 (ARRB1))

Andere Bezeichnung: Beta-arrestin 1

Hintergrund: Beta-arrestin 1, a member of arrestin family, is a cofactor of beta-adrenergic receptor kinase (BARK) in beta-adrenergic receptor desensitization and resensitization process. Beta-arrestin 1 acts as endocytic adapter for internalization of many G-protein coupled receptors. Beta-arrestin 1 is also associated with many other cellular processes like ubiquitination and down-regulation of the insulin-like growth factor-1 receptor, synaptic transmission in photoreceptor cells, working as a scaffold protein in G-protein coupled receptor signaling pathways. Two isoforms of beta-arrestin 1 have been identified, isoform 1 (47 kDa) and isoform 2 (46 kDa). Beta-arrestin 1 is highly expressed in liver, kidney, lungs and testes.

Molekulargewicht: 47 kDa

Gen-ID: 408

UniProt: P49407

Pathways: Positive Regulation of Peptide Hormone Secretion, Nuclear Hormone Receptor Binding, cAMP Metabolic Process, Myometrial Relaxation and Contraction, Synaptic Membrane, Regulation of G-Protein Coupled Receptor Protein Signaling, Phototransduction