ALDH1A1 Antikörper (AA 284-492)

Produktnummer ABIN5027017

Der Kaninchen Polyklonal anti-ALDH1A1 Antikörper wird verwendet zum Nachweis von ALDH1A1 in Proben von Human. Er wurde validiert für WB.

Kurzübersicht für ALDH1A1 Antikörper (AA 284-492) (ABIN5027017)

Target: ALDH1A1 (Aldehyde Dehydrogenase 1 Family, Member A1 (ALDH1A1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ALDH1A1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-ALDH1A1 Antikörper

Bindungsspezifität: AA 284-492

Aufreinigung: Protein A Chromatography

Immunogen: A partial length recombinant ALDH1A1 protein (amino acids 284-492) was used as the immunogen for this antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1-2 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: PBS containing 0.05 % BSA, PH 7.4

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Details zu ALDH1A1

Target: ALDH1A1 (Aldehyde Dehydrogenase 1 Family, Member A1 (ALDH1A1))

Andere Bezeichnung: ALDH1A1

Hintergrund: Aldehyde dehydrogenase 1A1 (ALDH1A1) is a member of a superfamily of detoxification enzymes found in various tissues that participate in the oxidation of both aliphatic and aromatic aldehydes. The human ALDH1A1, which is tetrameric and predominantly of cytosolic origin, functions mainly in acetaldehyde and neurotransmitter metabolism. It is also reported to play a major role in the production of retinoic acid, which is important for gene expression and tissue differentiation, and also in cyclophosphamide detoxification. ALDH1A1 is found in various tissues, including the central nervous system (CNS), with highest levels in the liver. In the brain, ALDH1A1 participates in the metabolism of catecholamines including dopamine (DA) and norepinephrine, and is uniquely expressed in a subset of dopaminergic (DAergic) neurons in the ventral mesencephalon where it converts 3,4-dihydroxyphenylacetaldehyde, a potentially toxic aldehyde, to 3,4-dihydroxyphenylacetic acid, a non toxic metabolite. ALDHA1 has been implicated in the development of alcohol dependence and other alcohol-use disorders, alcohol-induced flushing and sensitivity to alcohol.

Molekulargewicht: 55 kDa

Gen-ID: 216

UniProt: P00352

Pathways: Dopaminergic Neurogenesis