GCET2 Antikörper

Produktnummer ABIN5026982

Produktdetails anti-GCET2 Antikörper

Target: GCET2 (Germinal Center Expressed Transcript 2 (GCET2))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser GCET2 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC)

Aufreinigung: Protein G Chromatography

Immunogen: A full length human HGAL protein was used as the immunogen for this antibody

Klon: ABM43E6

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise: IHC: 5 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: PBS containing 0.05 % BSA, PH 7.4

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Details zu GCET2

Target: GCET2 (Germinal Center Expressed Transcript 2 (GCET2))

Andere Bezeichnung: HGAL (GCET2 Produkte)

Synonyme: Gcet antikoerper, Gcet2 antikoerper, M17 antikoerper, M17-L antikoerper, GCAT2 antikoerper, GCET2 antikoerper, HGAL antikoerper, germinal center associated, signaling and motility antikoerper, germinal center associated signaling and motility antikoerper, germinal center-associated, signaling and motility antikoerper, Gcsam antikoerper, GCSAM antikoerper

Hintergrund: Human germinal center-associated lymphoma (HGAL) is specifically expressed only in germinal center (GC), B lymphocytes and GC-derived lymphomas. It is located on chromosome 3q13, comprises 6 exons and encodes a cytoplasmic protein of 178 amino acids that contains an immunoreceptor tyrosine-based activation motif (ITAM). HGAL decreases lymphocyte motility by inhibiting the ability of myosin to translocate actin via direct interaction with F-actin and myosin II and by activating RhoA signaling via direct interactions with RhoA-specific guanine nucleotide exchange factors. It also regulates B-cell receptor (BCR) signaling by directly binding to and enhancing Syk kinase activity and activation of its downstream effectors (Ref-1). HGAL expression by tumor cells correlates with a favorable prognosis in patients with diffuse large B-cell and classical Hodgkin lymphomas.

Gen-ID: 257144

UniProt: Q8N6F7