PF4 Antikörper

Produktnummer ABIN5026898

Dieser Huhn Polyklonal Antikörper detektiert spezifisch PF4 in WB, IHC, ELISA und Aggl. Es zeigt Reaktivität gegenüber Proben von Säugetier.

Kurzübersicht für PF4 Antikörper (ABIN5026898)

Target: PF4 (Platelet Factor 4 (PF4))

Reaktivität: Säugetier

Wirt: Huhn

Klonalität: Polyklonal

Konjugat: Dieser PF4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Agglutination (Aggl)

Produktdetails anti-PF4 Antikörper

Produktmerkmale: IgY-antibody

Aufreinigung: Precipitation with ammoniumsulfate , dialyse and fitration

Immunogen: raw, native protein

Isotyp: IgY

Anwendungsinformationen

Applikationshinweise: Perform a chessboard titation before the first application

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: PBS, pH 7.4, 0.1 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C/-20 °C

Details zu PF4

Target: PF4 (Platelet Factor 4 (PF4))

Andere Bezeichnung: Platelet-factor 4

Hintergrund: Platelet-Factor 4 (PF4) complex is the antigen in heparin-induced thrombocytopenia (HIT), an idiosyncratic autoimmune reaction to the administration of the anticoagulant heparin. Its autoantibodies have also been found in patients with thrombosis with similar HIT although they have received no prior administration of heparin. Its major physiologic role appears to be neutralization of heparin-like molecules on the endothelial surface of blood vessels, thereby inhibiting local antithrombin III activity and promoting coagulation. As a strong chemoattractant for neutrophils and fibroblasts, PF4 probably has a role in inflammation and wound repair. It is usually found in a complex with proteoglycan.