TNNI3K Antikörper (AbBy Fluor® 750)

Produktnummer ABIN5011794

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch TNNI3K in WB und IF (p). Er zeigt eine Reaktivität gegenüber Human, Maus und Ratte.

Kurzübersicht für TNNI3K Antikörper (AbBy Fluor® 750) (ABIN5011794)

Target: TNNI3K (TNNI3 Interacting Kinase (TNNI3K))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TNNI3K Antikörper ist konjugiert mit AbBy Fluor® 750

Applikation: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Produktdetails anti-TNNI3K Antikörper (AbBy Fluor® 750)

Kreuzreaktivität: Human, Maus, Ratte

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human TNNI3K

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF(IHC-P) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu TNNI3K

Target: TNNI3K (TNNI3 Interacting Kinase (TNNI3K))

Andere Bezeichnung: TNNI3K

Hintergrund:

Synonyms: Cardiac ankyrin repeat kinase, CARK, MGC142099, MGC33828, Serine/threonine protein kinase TNN13K, Serine/threonine-protein kinase TNNI3K, TNI3K_HUMAN, TNNI3 interacting kinase, TNNI3-interacting kinase, Tnni3k.

Background: TNNI3K, also known as CARK, is a 936 amino acid serine/threonine-protein kinase that is highly expressed in heart. Overexpression of TNNI3K leads to improved cardiac function by enhancing beating frequency and increasing contractile force and epinephrine response. TNNI3K suppresses phosphorylation of cardiac troponin I and p38/JNK-mediated apoptosis, therefore protecting the myocardium from ischemic injury. Administration of TNNI3K to mice with myocardial infarction improves cardiac performance and attentuates ventricular remodeling, suggesting that TNNI3K could be a promising target in the treatment of cardiac diseases. There are four isoforms of TNNI3K that are produced as a result of alternative splicing events.

Gen-ID: 51086