UNG Antikörper (N-Term)

Produktnummer ABIN501108

Dieses Anti-UNG-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von UNG in WB, IHC (p) und EIA. Geeignet für Human, Maus und Ratte.

Kurzübersicht für UNG Antikörper (N-Term) (ABIN501108)

Target: UNG (Uracil-DNA Glycosylase (UNG))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser UNG Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Produktdetails anti-UNG Antikörper

Bindungsspezifität: N-Term

Spezifität: This antibody detects Uracil-DNA glycosylase (UNG) at N-term. The antibody will not cross-react with UNG2.

Kreuzreaktivität (Details): Species reactivity (tested):Human, mouse, rat

Aufreinigung: Affinity chromatography

Immunogen: UNG1 antibody was raised against a 13 amino acid peptide from near the amino terminus of human UNG1.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA. Western blot: 1 - 2 μg/mL. Immunohistochemistry on paraffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS containing 0.02 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Details zu UNG

Target: UNG (Uracil-DNA Glycosylase (UNG))

Hintergrund: The human uracil-DNA glycosylase (UNG) gene encodes both mitochondrial (UNG1) and nuclear (UNG2) forms through differentially regulated promotes and alternative splicing. While UNG2 is the major enzyme in the base excision repair pathway that removes uracil residues from nuclear DNA that arise through either misincorporation during replication or cytosine deamination, inhibition of UNG1 by uracil glycosylase inhibitor did not lead to increased levels of spontaneous or induced mitochondrial DNA mutations. However, decreased levels of UNG activity and increased oxidative damage to mitochondrial DNA were seen in older mice, suggesting that mitochondrial DNA repair mechanisms may be involved in various neurodegenerative disorders in an age-dependent manner.Synonyms: DGU, UDG, UNG1, UNG15

Gen-ID: 7374

NCBI Accession: NP_003353

Pathways: DNA Reparatur, Production of Molecular Mediator of Immune Response