TTBK1 Antikörper (C-Term)

Produktnummer ABIN501089

Der Kaninchen Polyklonal anti-TTBK1 Antikörper wird verwendet zum Nachweis von TTBK1 in Proben von Human und Maus. Er wurde validiert für WB, IHC (p) und EIA.

Kurzübersicht für TTBK1 Antikörper (C-Term) (ABIN501089)

Target: TTBK1 (tau Tubulin Kinase 1 (TTBK1))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TTBK1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Produktdetails anti-TTBK1 Antikörper

Bindungsspezifität: C-Term

Spezifität: This antibody detects TTBK1. It is predicted to not cross-react with TTBK2.

Kreuzreaktivität (Details): Species reactivity (tested):Human, mouse

Aufreinigung: Affinity chromatography

Immunogen: TTBK1 antibody was raised against a 16 amino acid peptide near the carboxy terminus of human TTBK1.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA. Western blot: 1 - 2 μg/mL. Immunohistochemistry on paraffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS containing 0.02 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Details zu TTBK1

Target: TTBK1 (tau Tubulin Kinase 1 (TTBK1))

Andere Bezeichnung: TTBK1

Hintergrund: Tau tubulin kinase (TTBK1) belongs to the casein kinase 1 superfamily and is involved in the phosphorylation of specific serine/threonine residues in paired helical filaments of the tau protein. It is specifically expressed in the brain and induces tau aggregation in human neuronal cells in a dose-dependent manner. TTBK1 levels have been found to be upregulated in the brains of Alzheimer's disease (AD) patients, and mice expressing human TTBK1 protein showed significant age-dependent memory impairment. These mice displayed increased levels of the CDK5 activators p25 and p35, and reduced levels of the NMDA receptor types 2B and 2D, suggesting that TTBK1 may play a role in memory dysfunction in AD patients. Multiple isoforms of TTBK1 are known to exist.Synonyms: BDTK, Brain-derived tau kinase, KIAA1855, Tau-tubulin kinase 1

Gen-ID: 84630

UniProt: Q5TCY1