TMEM38A Antikörper (C-Term)

Produktnummer ABIN500984

Der Kaninchen Polyklonal Anti-TMEM38A-Antikörper wurde für WB und EIA validiert. Er ist geeignet, TMEM38A in Proben von Human, Ratte und Maus zu detektieren.

Kurzübersicht für TMEM38A Antikörper (C-Term) (ABIN500984)

Target: TMEM38A (Transmembrane Protein 38A (TMEM38A))

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TMEM38A Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA)

Produktdetails anti-TMEM38A Antikörper

Bindungsspezifität: C-Term

Spezifität: This antibody detects TMEM38A.

Aufreinigung: Peptide affinity chromatography

Immunogen: TMEM38A antibody was raised against a 17 amino acid peptide from near the carboxy terminus of human TMEM38A.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA. Western blot: 1 - 2 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu TMEM38A

Target: TMEM38A (Transmembrane Protein 38A (TMEM38A))

Andere Bezeichnung: TMEM38A

Hintergrund: TMEM38A and TMEM38B are two recently identified trimeric intracellular cation (TRIC) channel subtypes. TMEM38A is preferentially expressed in excitable tissues such as striated muscle and brain and localizes to the sarcoplasmic reticulum (SR) in muscle tissues. Mice deficient in both TMEM38A and TMEM38B suffer embryonic cardiac failure, the cardiac myocytes display severe dysfunction in SR Ca2+ handling, weakened Ca2+ release, and reduced K+ permeability indicating that the TRIC cation channels are likely to act as counter-ion channels that function in synchronization with Ca2+ release from intracellular stores. Other experiments have shown that TMEM38A and TMEM38B can act with junctophilin proteins to support efficient ryanodine receptor-mediated Ca2+ release in muscle cells.Synonyms: TRIC-A, TRICA, Transmembrane protein 38A, Trimeric intracellular cation channel type A

Gen-ID: 79041