ANO1 Antikörper (N-Term)

Produktnummer ABIN500970

Dieses Anti-ANO1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von ANO1 in IF, WB und EIA. Geeignet für Human und Maus.

Kurzübersicht für ANO1 Antikörper (N-Term) (ABIN500970)

Target: ANO1 (Anoctamin 1, Calcium Activated Chloride Channel (ANO1))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ANO1 Antikörper ist unkonjugiert

Applikation: Immunofluorescence (IF), Western Blotting (WB), Enzyme Immunoassay (EIA)

Produktdetails anti-ANO1 Antikörper

Bindungsspezifität: N-Term

Spezifität: At least three isoforms are known to exist. This antibody will not cross-react with TMEM16B.

Kreuzreaktivität (Details): Species reactivity (tested):Human, Mouse.

Aufreinigung: Peptide affinity chromatography

Immunogen: 17 amino acid peptide from near the amino terminus of Human TMEM16A

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA. Western blot: 1 - 2 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % Sodium Azide as preservative

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu ANO1

Target: ANO1 (Anoctamin 1, Calcium Activated Chloride Channel (ANO1))

Andere Bezeichnung: ANO1 / DOG1

Hintergrund: Calcium-activated chloride channels (CaCC) are present in many cell types and mediate physiological functions such as epithelial secretion, sensory signal transduction, and smooth muscle contraction. Subunits of these CaCC's include the transmembrane proteins TMEM16A and TMEM16B. TMEM16A is expressed in epithelial cells of the kidney and lung, pancreas, and sensory neurons and its mRNA is seen in foregut, airway epithelia, and tracheal smooth muscle, mice lacking TMEM16A fail to survive past ten days and show aerophagia and little weight gain. TMEM16A is also overexpressed or amplified in multiple cancers associated with poor survival such as oral cancers and gastrointestinal stromal tumors, suggesting the development of CaCC modulators may be a viable therapeutic strategy.Synonyms: Anoctamin-1, DOG-1, Discovered on gastrointestinal stromal tumors protein 1, ORAOV2, Oral cancer overexpressed protein 2, TAOS2, TMEM16A, Transmembrane protein 16A, Tumor-amplified and overexpressed sequence 2

Gen-ID: 55107

NCBI Accession: NP_060513