GPR124 Antikörper (Center)

Produktnummer ABIN500897

Der Kaninchen Polyklonal Anti-GPR124-Antikörper wurde für WB, IHC (p) und EIA validiert. Er ist geeignet, GPR124 in Proben von Human und Ratte zu detektieren.

Kurzübersicht für GPR124 Antikörper (Center) (ABIN500897)

Target: GPR124 (G Protein-Coupled Receptor 124 (GPR124))

Reaktivität: Human, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GPR124 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Produktdetails anti-GPR124 Antikörper

Bindungsspezifität: Center

Spezifität: ELISA. Western blot: 1 - 2 μg/mL. Immunohistochemistry on paraffin sections.

Kreuzreaktivität (Details): Species reactivity (tested):Human, rat

Aufreinigung: Peptide affinity chromatography

Immunogen: TEM5 antibody was raised against a 14 amino acid peptide near the center of human TEM5.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS containing 0.02 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Details zu GPR124

Target: GPR124 (G Protein-Coupled Receptor 124 (GPR124))

Andere Bezeichnung: GPR124 / TEM5

Hintergrund: Tumor endothelial markers (TEMs) are significantly up-regulated during angiogenesis and neoangiogensis that are crucial for the growth of solid tumors. TEMs localized on the cell surface and conserved across species are of particular interest for future development of anti-angiogenic therapies. These include TEMs such as TEM1, TEM5, TEM7 and TEM8. TEM5 is a member of the adhesion family of G protein coupled receptors and is localized on the surface of endothelial cells. TEM5 is a seven-pass transmembrane receptor, unlike TEM1, TEM7 and TEM8 which span the membrane once. TEM5 is abundantly expressed in tumor vessels, heart, placenta, ovary, small intestine, and colon. Proteolytically processed soluble TEM5 mediates endothelial cell survival during angiogenesis by linking integrin to glycosaminoglycans.Synonyms: G-protein coupled receptor 124, KIAA1531, Tumor endothelial marker 5

Gen-ID: 25960

UniProt: Q96PE1