CD248 Antikörper (N-Term)

Produktnummer ABIN500887

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch CD248 in WB, IHC (p) und EIA. Es zeigt Reaktivität gegenüber Proben von Human, Maus und Ratte.

Kurzübersicht für CD248 Antikörper (N-Term) (ABIN500887)

Target: CD248 (CD248 Molecule, Endosialin (CD248))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CD248 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Produktdetails anti-CD248 Antikörper

Bindungsspezifität: N-Term

Spezifität: This antibody detects CD248 / TEM1 at N-term. It recognizes only the larger isoform.

Kreuzreaktivität (Details): Species reactivity (tested):Human, Mouse, Rat

Aufreinigung: Peptide Affinity Chromatography

Immunogen: A 14 amino acid peptide near the amino terminus of the Human TEM1.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA. Western blot: 0.5 - 1 μg/mL. Immunohistochemistry on paraffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS, 0.02 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu CD248

Target: CD248 (CD248 Molecule, Endosialin (CD248))

Andere Bezeichnung: CD248 / TEM1

Hintergrund: Tumor endothelial marker (TEM) 1 was originally identified as a human embryonic fibroblast-specific antigen and was later determined to be endosialin, a single-pass transmembrane glycoprotein that has multiple extracellular domains, including three EGF-like domains, a sushi-like domain, and a C lectin-like domain. TEM proteins are significantly up-regulated during angiogenesis and neoangiogenesis that are crucial for the growth of solid tumors. While TEM1 is not required for angiogenesis during fetal development, postnatal growth or wound healing, it plays a role in tumor growth, invasion, and metastasis. Fibronectin and collagen types I and IV act as specific ligands of TEM1, leading to suggestions that these molecules may cause changes in the extracellular matrix, cell adhesion and migration during tumor invasion. At least two isoforms of TEM1 are known to exist.Synonyms: CD164L1, Endosialin, Tumor endothelial marker 1

Gen-ID: 57124

NCBI Accession: NP_065137